Fig. S1 Morphological appearance of rBMSCs in three age groups (A) shows cell morphology at the first passage from young rBMSCs (< 5 years), middle rBMSCs (8-10 years), and old rBMSCs (> 12 years), respectively. Original magnification, 10×. (B) rBMSCs obtained from three age groups were analyzed for cell size. Shown is a representative single-parameter histogram. (C) A representative flow cytometry plot of rBMSCs in three age groups according to light scatter characteristics reflecting cytoplasmic granularity and cell size.

Fig. S2 HPLC separation of histones from rBMSCs cells in young and old group. (A) All core histones are observed. (B) Several variants of histone H2B, H2A, H3 and H4 were separated and their retention times were labeled on the top of their corresponding peaks.

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