• Open Access

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

Authors

  • Moustapha Kassem,

    1. Department of Endocrinology and Metabolism, University Hospital of Odense, DK-5000 Odense, Denmark
    2. Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, KSA
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  • Pierre J. Marie

    1. Laboratory of Osteoblast Biology and Pathology, INSERM, U606, Paris F-75475, France
    2. University Paris Diderot, UMR606, Paris F-75475, France
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Pierre Marie, Inserm U606, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France. Tel.: +33 1 49 95 63 89; fax: +33 1 49 95 84 52; e-mail: pierre.marie@inserm.fr

Summary

Human aging is associated with bone loss leading to bone fragility and increased risk of fractures. The cellular and molecular causes of age-related bone loss are current intensive topic of investigation with the aim of identifying new approaches to abolish its negative effects on the skeleton. Age-related osteoblast dysfunction is the main cause of age-related bone loss in both men and women beyond the fifth decade and results from two groups of pathogenic mechanisms: extrinsic mechanisms that are mediated by age-related changes in bone microenvironment including changes in levels of hormones and growth factors, and intrinsic mechanisms caused by the osteoblast cellular senescence. The aim of this review is to provide a summary of the intrinsic senescence mechanisms affecting osteoblastic functions and how they can be targeted to abolish age-related osteoblastic dysfunction and bone loss associated with aging.

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