• Please log in or register to access this feature.

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

  1. Bruno Bernardes de Jesus1,
  2. Kerstin Schneeberger1,
  3. Elsa Vera1,2,
  4. Agueda Tejera1,
  5. Calvin B. Harley3,
  6. Maria A. Blasco1

Article first published online: 14 APR 2011

DOI: 10.1111/j.1474-9726.2011.00700.x

Issue

Aging Cell

Aging Cell

Volume 10, Issue 4, pages 604–621, August 2011

Additional Information

How to Cite

de Jesus, B. B., Schneeberger, K., Vera, E., Tejera, A., Harley, C. B. and Blasco, M. A. (2011), The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell, 10: 604–621. doi: 10.1111/j.1474-9726.2011.00700.x

Author Information

  1. 1

    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid E-28029, Spain

  2. 2

    Life Length, Agustín de Betancourt 21, Madrid E-28003, Spain

  3. 3

    Telome Health, Menlo Park, CA 94025, USA

*Maria A. Blasco, Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid, E-28029, Spain. Tel.: +34-917328034; fax: +34-917328028; e-mail:mblasco@cnio.es

Publication History

  1. Issue published online: 12 JUL 2011
  2. Article first published online: 14 APR 2011
  3. Accepted manuscript online: 22 MAR 2011 09:26AM EST
  4. Accepted for publication 9th February 2011

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (1026K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Melis Kuban, Gaye Öngen, Ikhlas A. Khan, Erdal Bedir, Microbial transformation of cycloastragenol, Phytochemistry, 2013, 88, 99

    CrossRef

  2. 2
    Zhiyou Cai, Liang-Jun Yan, Anna Ratka, Telomere Shortening and Alzheimer’s Disease, NeuroMolecular Medicine, 2013, 15, 1, 25

    CrossRef

  3. 3
    Weisi Lu, Yi Zhang, Dan Liu, Zhou Songyang, Ma Wan, Telomeres—structure, function, and regulation, Experimental Cell Research, 2013, 319, 2, 133

    CrossRef

  4. 4
    Principles and Practice of Phytotherapy, 2013,

    CrossRef

  5. 5
    L.C. Bollheimer, D. Volkert, T. Bertsch, C.C. Sieber, R. Büttner, Alternsumkehr und Lebensspannenverlängerung, Zeitschrift für Gerontologie und Geriatrie, 2012,

    CrossRef

  6. 6
    Ergün Sahin, Ronald A. DePinho, Axis of ageing: telomeres, p53 and mitochondria, Nature Reviews Molecular Cell Biology, 2012, 13, 6, 397

    CrossRef

  7. 7
    F. Beier, M. Foronda, P. Martinez, M. A. Blasco, Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita, Blood, 2012, 120, 15, 2990

    CrossRef

  8. 8
    Andrew R. Mendelsohn, James W. Larrick, Ectopic Expression of Telomerase Safely Increases Health Span and Life Span, Rejuvenation Research, 2012, 15, 4, 435

    CrossRef

  9. 9
    Bruno Bernardes de Jesus, Maria A Blasco, Potential of telomerase activation in extending health span and longevity, Current Opinion in Cell Biology, 2012, 24, 6, 739

    CrossRef

  10. 10
    Alex Zhavoronkov, Zeljka Smit-McBride, Kieran J. Guinan, Maria Litovchenko, Alexey Moskalev, Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases, Journal of Molecular Medicine, 2012, 90, 12, 1361

    CrossRef

  11. 11
    José MP Freije, Carlos López-Otín, Reprogramming aging and progeria, Current Opinion in Cell Biology, 2012, 24, 6, 757

    CrossRef

  12. 12
    Branca Pereira, Miguel G. Ferreira, Sowing the seeds of cancer, Current Opinion in Oncology, 2012, 1

    CrossRef

  13. 13
    Bruno Bernardes de Jesus, Elsa Vera, Kerstin Schneeberger, Agueda M. Tejera, Eduard Ayuso, Fatima Bosch, Maria A. Blasco, Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer, EMBO Molecular Medicine, 2012, 4, 8
    Direct Link:
  14. 14
    Laura J. Fick, Gordon H. Fick, Zichen Li, Eric Cao, Bo Bao, Doug Heffelfinger, Heidi G. Parker, Elaine A. Ostrander, Karl Riabowol, Telomere Length Correlates with Life Span of Dog Breeds, Cell Reports, 2012, 2, 6, 1530

    CrossRef

  15. 15
    Fernando P. Hartwig, Fernanda Nedel, Tiago V. Collares, Sandra B. C. Tarquinio, Jacques E. Nör, Flávio F. Demarco, Telomeres and Tissue Engineering: The Potential Roles of TERT in VEGF-mediated Angiogenesis, Stem Cell Reviews and Reports, 2012, 8, 4, 1275

    CrossRef

  16. 16
    S. Mulambalah Chrispinus, N. Siamba Donald, M. Vulule John, The Molecular and Medical Aspects of the Aging Process, Research Journal of Medical Sciences, 2012, 6, 3, 117

    CrossRef

  17. 17
    Michael Fossel, Use of Telomere Length as a Biomarker for Aging and Age-Related Disease, Current Translational Geriatrics and Gerontology Reports, 2012, 1, 2, 121

    CrossRef

  18. 18
    Howard Wolinsky, Testing time for telomeres, EMBO reports, 2011, 12, 9, 897

    CrossRef

View Full Article with Supporting Information (HTML) Get PDF (1026K)