The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity
Version of Record online: 25 APR 2011
© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 10, Issue 4, pages 724–728, August 2011
How to Cite
Yang, C. C., Chen, D., Lee, S. S. and Walter, L. (2011), The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell, 10: 724–728. doi: 10.1111/j.1474-9726.2011.00711.x
- Issue online: 12 JUL 2011
- Version of Record online: 25 APR 2011
- Accepted manuscript online: 4 APR 2011 06:54AM EST
- Accepted for publication 26 March 2011
Fig. S1drp-1 RNAi affects mitochondrial morphology in muscle cells of the body wall. GFP expression of a Pmyo-3::GFPmt transgene in wild-type worms treated with empty vector in (A) or drp-1 RNAi in (B).
Fig. S2 The extended longevity and the sensitivity to heat stress of the age-1;drp-1 mutant compared to the age-1 mutant can be rescued by introduction of a transgene overexpressing drp-1.
Table S1 Quantitative data and statistical analyses of mean adult lifespan presented in Fig. 1.
Table S2 Effect of drp-1 RNAi on the mean lifespan of long-lived worms undergoing bacteria deprivation and long-lived mitochondrial mutant worms.
Table S3 Quantitative data and statistical analyses of survival on paraquat presented in Fig. 2.
Data S1 Materials and methods.
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