SEARCH

SEARCH BY CITATION

References

  • Akashi-Takamura S, Miyake K (2008) TLR accessory molecules. Curr. Opin. Immunol. 20, 420425.
  • Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA (2002) Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat. Med. 8, 878884.
  • Bates JT, Honko AN, Graff AH, Kock ND, Mizel SB (2008) Mucosal adjuvant activity of flagellin in aged mice. Mech. Ageing Dev. 129, 271281.
  • Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV (2008) An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320, 226230.
  • Conley ME (2007) Immunodeficiency: UNC-93B gets a toll call. Trends Immunol. 28, 99101.
  • van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov R, Shaw AC (2007a) Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J. Infect. Dis. 195, 15901597.
  • van Duin D, Thomas V, Mohanty S, Montgomery RR, Ginter S, Fikrig E, Allore HG, Medzhitov R, Shaw AC (2007b) Age-associated defect in human TLR1 function and expression. J. Immunol. 178, 970975.
  • Faham A, Altin JG (2010) Antigen-containing liposomes engrafted with flagellin-related peptides are effective vaccines that can induce potent antitumor immunity and immunotherapeutic effect. J. Immunol. 185, 17441754.
  • Falsey AR, Treanor JJ, Tornieporth N, Capellan J, Gorse GJ (2009) Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older. J. Infect. Dis. 200, 172180.
  • Feuillet V, Medjane S, Mondor I, Demaria O, Pagni PP, Galan JE, Flavell RA, Alexopoulou L (2006) Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc. Natl Acad. Sci. USA 103, 1248712492.
  • Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 128, 92105.
  • Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M (2002) Multiple control of interleukin-8 gene expression. J. Leukoc. Biol. 72, 847855.
  • Huleatt JW, Nakaar V, Desai P, Huang Y, Hewitt D, Jacobs A, Tang J, McDonald W, Song L, Evans RK, Umlauf S, Tussey L, Powell TJ (2008) Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin. Vaccine 26, 201214.
  • Jacobs MD, Harrison SC (1998) Structure of an IkappaBalpha/NF-kappaB complex. Cell 95, 749758.
  • Joo JH, Ryu JH, Kim CH, Kim HJ, Suh MS, Kim JO, Chung SY, Lee SN, Kim HM, Bae YS, Yoon JH (2011) Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa. Antioxid. Redox Signal. , in press.
  • Kawai T, Akira S (2007) Antiviral signaling through pattern recognition receptors. J. Biochem. 141, 137145.
  • Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG (2010) Bacterial flagellin stimulates toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J. Infect. Dis. 201, 534543.
  • Kong K-F, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR (2008) Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J. Virol. 82, 76137623.
  • Leng J, Stout-Delgado HW, Kavita U, Jacobs A, Tang J, Du W, Tussey L, Goldstein DR (2011) Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection. Vaccine, 29, 81478155.
  • Leon B, Ardavin C (2008) Monocyte-derived dendritic cells in innate and adaptive immunity. Immunol. Cell Biol. 86, 320324.
  • Linton PJ, Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat. Immunol. 5, 133139.
  • McDevitt MA, Xie J, Shanmugasundaram G, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R (2006) A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J. Exp. Med. 203, 11851196.
  • McGlauchlen KS, Vogel LA (2003) Ineffective humoral immunity in the elderly. Microbes Infect. 5, 12791284.
  • Metz CN, Bucala R (1997) Role of macrophage migration inhibitory factor in the regulation of the immune response. Adv. Immunol. 66, 197223.
  • Mizel SB, Bates JT (2010) Flagellin as an adjuvant: cellular mechanisms and potential. J. Immunol. 185, 56775682.
  • Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC (2010) Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J. Immunol. 184, 25182527.
  • Pawelec G (1999) Immunosenescence: impact in the young as well as the old? Mech. Ageing Dev. 108, 17.
  • Qian F, Wang X, Zhang l, Lin A, Zhao H, Fikrig E, Montgomery RR (2011) Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J. Infect. Dis. 203, 14151424.
  • Rhee SH, Keates AC, Moyer MP, Pothoulakis C (2004) MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. J. Biol. Chem. 279, 2517925188.
  • Rosenstiel P, Derer S, Till A, Hasler R, Eberstein H, Bewig B, Nikolaus S, Nebel A, Schreiber S (2008) Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes. Genes Immun. 9, 103114.
  • Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F (2010) Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol. 11, 30.
  • Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM (2010) Aging of the innate immune system. Curr. Opin. Immunol. 22, 507513.
  • Shaw AC, Panda A, Joshi S, Qian F, Allore H, Montgomery RR (2011) Dysregulation of human toll-like receptor function in aging. Ageing Res. Rev. 10, 346353.
  • Skountzou I, Martin MD, Wang B, Ye L, Koutsonanos D, Weldon W, Jacob J, Compans RW (2009) Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine 28, 41034112.
  • Song L, Zhang Y, Yun NE, Poussard AL, Smith JN, Smith JK, Borisevich V, Linde JJ, Zacks MA, Li H, Kavita U, Reiserova L, Liu X, Dumuren K, Balasubramanian B, Weaver B, Parent J, Umlauf S, Liu G, Huleatt J, Tussey L, Paessler S (2009) Superior efficacy of a recombinant flagellin: H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin. Vaccine 27, 58755884.
  • Takahashi K, Shibata T, Akashi-Takamura S, Kiyokawa T, Wakabayashi Y, Tanimura N, Kobayashi T, Matsumoto F, Fukui R, Kouro T, Nagai Y, Takatsu K, Saitoh S, Miyake K (2007) A protein associated with toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. J. Exp. Med. 204, 29632976.
  • Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int. Immunol. 17, 114.
  • Taylor DN, Treanor JJ, Strout C, Johnson C, Fitzgerald T, Kavita U, Ozer K, Tussey L, Shaw A (2011) Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI). Vaccine 29, 48974902.
  • Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Gewirtz AT (2003) TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am. J. Physiol. 285, G282G290.
  • Zeng H, Wu H, Sloane V, Jones R, Yu Y, Lin P, Gewirtz AT, Neish AS (2006) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am. J. Physiol. 290, G96G108.