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Fig. S1 SirT1 mRNA expression in CM and non-cardiomyocyte (NCM) fraction from wild type mouse hearts.

Fig. S2 Analysis of SirT1 expression upon mIGF-1 or IGF-1 exposure.

Fig. S3 Cellular localization of SirT1 in neonatal CM and HL-1 CM.

Fig. S4 (A) Representative Western blot of SirT1, phospho-SirT1 on Ser46 detected in cell lysates from HL-1 CM transfected with mIGF-1 in presence of SP600125 (JNK inhibitor, 10 mM). (B) Representative Western blot of SirT1, phospho-SirT1 on Ser46, JNK1 and JNK2 detected in cell lysates from HL-1 CM transfected with mIGF-1 together with JNK1 or JNK2 specific siRNAs. Densitometric quantification is shown. Results are means ± SE of 3 independent experiments (*,**,***p versus untreated CM).

Table S1 Reagents and antibodies.

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