Fig. S1 SET-26 is expressed in both germline and somatic tissues.

Fig. S2 set-9 and set-26 have redundant functions in affecting worm lifespan.

Fig. S3 set-26(tm2467) mutation partially depends on daf-16 to extend glp-1(e2141) worm lifespan, but does not affect daf-16 RNA level.

Fig. S4 set-26(tm2467) mutation affects the expression of some of the known DAF-16 target genes.

Table S1 Lifespan screen of 50 RNAi clones in wild type worms targeting putative histone methyltransferase and demethylase genes.

Table S2 Lifespan data for the figures and supplementary figures.

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