These authors contributed equally to this work.
A senescent cell bystander effect: senescence-induced senescence
Version of Record online: 9 FEB 2012
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 2, pages 345–349, April 2012
How to Cite
Nelson, G., Wordsworth, J., Wang, C., Jurk, D., Lawless, C., Martin-Ruiz, C. and von Zglinicki, T. (2012), A senescent cell bystander effect: senescence-induced senescence. Aging Cell, 11: 345–349. doi: 10.1111/j.1474-9726.2012.00795.x
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- Issue online: 15 MAR 2012
- Version of Record online: 9 FEB 2012
- Accepted for publication 4 January 2012
- DNA damage;
- cell signalling
Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation-competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction-mediated cell–cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo.