• Open Access

Comparative and meta-analytic insights into life extension via dietary restriction

Authors

  • Shinichi Nakagawa,

    1. Department of Zoology, National Research Centre for Growth and Development, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Search for more papers by this author
  • Malgorzata Lagisz,

    1. Department of Zoology, National Research Centre for Growth and Development, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Search for more papers by this author
  • Katie L. Hector,

    1. Department of Zoology, National Research Centre for Growth and Development, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Search for more papers by this author
  • Hamish G. Spencer

    1. Department of Zoology, National Research Centre for Growth and Development, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Search for more papers by this author

Shinichi Nakagawa, National Research Centre for Growth and Development, Department of Zoology, University of Otago, PO Box 56, Dunedin 9054, New Zealand. Tel.: +64 3 479 5046; fax: +64 3 479 7584; e-mail:shinichi.nakagawa@otago.ac.nz

Summary

Dietary restriction (DR) extends the lifespan of a wide range of species, although the universality of this effect has never been quantitatively examined. Here, we report the first comprehensive comparative meta-analysis of DR across studies and species. Overall, DR significantly increased lifespan, but this effect is modulated by several factors. In general, DR has less effect in extending lifespan in males and also in non-model organisms. Surprisingly, the proportion of protein intake was more important for life extension via DR than the degree of caloric restriction. Furthermore, we show that reduction in both age-dependent and age-independent mortality rates drives life extension by DR among the well-studied laboratory model species (yeast, nematode worms, fruit flies and rodents). Our results suggest that convergent adaptation to laboratory conditions better explains the observed DR–longevity relationship than evolutionary conservation although alternative explanations are possible.

Ancillary