Is cellular senescence an example of antagonistic pleiotropy?
Article first published online: 15 MAR 2012
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 3, pages 378–383, June 2012
How to Cite
Giaimo, S. and d’Adda di Fagagna, F. (2012), Is cellular senescence an example of antagonistic pleiotropy?. Aging Cell, 11: 378–383. doi: 10.1111/j.1474-9726.2012.00807.x
- Issue published online: 11 MAY 2012
- Article first published online: 15 MAR 2012
- Accepted manuscript online: 14 FEB 2012 03:34AM EST
- Accepted for publication 1 February 2012
- antagonistic pleiotropy;
- cellular senescence;
- DNA Damage Response;
- tumour suppression
It is generally accepted that the permanent arrest of cell division known as cellular senescence contributes to aging by an antagonistic pleiotropy mechanism: cellular senescence would act beneficially early in life by suppressing cancer, but detrimentally later on by causing frailty and, paradoxically, cancer. In this review, we show that there is room to rethink this common view. We propose a critical appraisal of the arguments commonly brought in support of it, and we qualitatively analyse published results that are of relevance to understand whether or not cellular senescence-associated genes really act in an antagonistic-pleiotropic manner in humans.