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Fig. S1 Analysis of TRITC-wt Aβ (1  μM) binding to SHSY5Y cells both in the presence and absence of increasing concentration unlabelled variant Aβ.

Fig. S2. Analysis of variant (50  μM) and wt Aβ (50  μM) aggregation kinetics in vitro.

Fig. S3 Particle size analysis of wt Aβ, variant Aβ and wt Aβ/variant Aβ mixtures analyzed by dynamic light scattering.

Fig. S4 Variant Aβ does not aggregate in cellulo.

Fig. S5 The dominant negative effect of variant Aβ is specific.

Fig. S6 Variant Aβ shows increased binding to GM1.

Fig. S7 Variant Aβ displays an evident diminished aggregation capability in the presence of synaptosmes.

Fig. S8 Variant Aβ displays an evident diminished aggregation capability in the presence of synaptosmes.

Data S1 Materials and methods.

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