Present Address: Department of Stem Cell & Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.
Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD
Article first published online: 2 AUG 2012
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 5, pages 770–782, October 2012
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How to Cite
Jang, Y. C., Liu, Y., Hayworth, C. R., Bhattacharya, A., Lustgarten, M. S., Muller, F. L., Chaudhuri, A., Qi, W., Li, Y., Huang, J.-Y., Verdin, E., Richardson, A. and Van Remmen, H. (2012), Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell, 11: 770–782. doi: 10.1111/j.1474-9726.2012.00843.x
- Issue published online: 16 SEP 2012
- Article first published online: 2 AUG 2012
- Accepted manuscript online: 5 JUN 2012 09:50AM EST
- Accepted for publication 27 May 2012
Fig. S1 Comparison of individual hindlimb muscle from WT, Sod1−/−, and Sod1−/− DR mice at 14 months of age. Values are represented as mean ± standard error (n = 4–6).
Fig. S2 Distribution of fiber cross-sectional area measured from Laminin staining shown in Fig. 2E.
Fig. S3 Immunoblot analyses of different mitochondrial ETC. proteins and ETC. activity.
Fig. S4 (A) Immunofluorescence images of neuromuscular junctions from WT, Sod1−/−, and Sod1−/− DR gastrocnemius muscle at 14 months of age. (B) A quantification of percent denervated NMJs WT, Sod1−/−, and Sod1−/− DR gastrocnemius muscle at 14 months of age. (C) A quantification of motor neurons from Nissl stained images from WT, Sod1−/−, and Sod1−/− DR gastrocnemius muscle at 11–16 months of age. Data are represented as mean ± standard error (n = 4–6).
Fig. S5 Xxxxxxxxx.
Data S1. Supplemental materials and methods.
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