These authors contributed equally to this work.
Glucose delays age-dependent proteotoxicity
Article first published online: 1 AUG 2012
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 5, pages 856–866, October 2012
How to Cite
Tauffenberger, A., Vaccaro, A., Aulas, A., Velde, C. V. and Parker, J. A. (2012), Glucose delays age-dependent proteotoxicity. Aging Cell, 11: 856–866. doi: 10.1111/j.1474-9726.2012.00855.x
Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms
- Issue published online: 16 SEP 2012
- Article first published online: 1 AUG 2012
- Accepted manuscript online: 26 JUN 2012 01:04PM EST
- Accepted for publication 11 June 2012
- Caenorhabditis elegans;
- protein folding;
Nutrient availability influences an organism’s life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is associated with extended lifespan in simple animals and a reduced incidence of age-dependent pathologies in humans. We report here that glucose enrichment delays mutant polyglutamine, TDP-43, FUS, and amyloid-β toxicity in Caenorhabditis elegans models of neurodegeneration by reducing protein misfolding. Dysregulated metabolism is common to neurodegeneration and we show that glucose enrichment is broadly protective against proteotoxicity.