These authors contributed equally to this work.
Glucose delays age-dependent proteotoxicity
Article first published online: 1 AUG 2012
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 5, pages 856–866, October 2012
How to Cite
Tauffenberger, A., Vaccaro, A., Aulas, A., Velde, C. V. and Parker, J. A. (2012), Glucose delays age-dependent proteotoxicity. Aging Cell, 11: 856–866. doi: 10.1111/j.1474-9726.2012.00855.x
Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms
- Issue published online: 16 SEP 2012
- Article first published online: 1 AUG 2012
- Accepted manuscript online: 26 JUN 2012 01:04PM EST
- Accepted for publication 11 June 2012
Fig. S1 Worms grown on glucose plates have elevated levels of internal glucose and pyruvate.
Fig. S2 Glucose has no effect on wild type polyglutamine, TDP-43 or FUS strains.
Fig. S3 Glucose reduces amyloid-β toxicity.
Fig. S4 L-glucose does not reduce neuronal proteotoxicity in C. elegans transgenics.
Fig. S5 GE reduces lifespan of long-lived daf-2 mutants but not strains with shorter lifespans.
Fig. S6 Glycerol does not reduce mutant TDP-43 toxicity.
Fig. S7 Other sugars reduce proteotoxicity and lifespan.
Fig. S8 Glucose rescues unc-54 mutant phenotypes.
Fig. S9 Glucose does not affect daf-16, hsf-1 or target gene expression.
Fig. S10 Glucose neuroprotection requires protein homeostasis genes.
Table S1 Lifespan analysis for all experiments.
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