SEARCH

SEARCH BY CITATION

References

  • Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA (2009) Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am. J. Pathol. 175, 18101816.
  • Bezprozvanny I, Mattson MP (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease. Trends Neurosci. 31, 454463.
  • Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS (1996) Familial Alzheimer’s disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 10051013.
  • Brunello L, Zampese E, Florean C, Pozzan T, Pizzo P, Fasolato C (2009) Presenilin-2 dampens intracellular Ca2 + stores by increasing Ca2 + leakage and reducing Ca2 + uptake. J. Cell Mol. Med. 13, 33583369.
  • Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B, Konnerth A (2012) Critical role of soluble amyloid-beta for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease. Proc. Natl Acad. Sci. U.S.A. 109, 87408745.
  • Camandola S, Mattson MP (2011) Aberrant subcellular neuronal calcium regulation in aging and Alzheimer’s disease. Biochim. Biophys. Acta 1813, 965973.
  • Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP (2000) Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J. Biol. Chem. 275, 1819518200.
  • Cheung KH, Shineman D, Muller M, Cardenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK (2008) Mechanism of Ca2 + disruption in Alzheimer’s disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58, 871883.
  • Fellin T, Pascual O, Gobbo S, Pozzan T, Haydon PG, Carmignoto G (2004) Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43, 729743.
  • Giacomello M, Drago I, Bortolozzi M, Scorzeto M, Gianelle A, Pizzo P, Pozzan T (2010) Ca2 + hot spots on the mitochondrial surface are generated by Ca2 + mobilization from stores, but not by activation of store-operated Ca2 + channels. Mol. Cell 38, 280290.
  • Gleichmann M, Zhang Y, Wood WH 3rd, Becker KG, Mughal MR, Pazin MJ, van Praag H, Kobilo T, Zonderman AB, Troncoso JC, Markesbery WR, Mattson MP (2012) Molecular changes in brain aging and Alzheimer’s disease are mirrored in experimentally silenced cortical neuron networks. Neurobiol. Aging 33, 205. e201205. e218.
  • Gomez-Gonzalo M, Losi G, Chiavegato A, Zonta M, Cammarota M, Brondi M, Vetri F, Uva L, Pozzan T, de Curtis M, Ratto GM, Carmignoto G (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol. 8, e1000352.
  • Guo Q, Furukawa K, Sopher BL, Pham DG, Xie J, Robinson N, Martin GM, Mattson MP (1996) Alzheimer’s PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. NeuroReport 8, 379383.
  • Jung CK, Fuhrmann M, Honarnejad K, Van Leuven F, Herms J (2011) Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo. J. Neurochem. 119, 10641073.
  • Khachaturian ZS (1987) Hypothesis on the regulation of cytosol calcium concentration and the aging brain. Neurobiol. Aging 8, 345346.
  • Khachaturian ZS (1994) Calcium hypothesis of Alzheimer’s disease and brain aging. Ann. N.Y. Acad. Sci. 747, 111.
  • La Ferla FM (2002) Calcium dyshomeostasis and intracellular signalling in Alzheimer’s disease. Nat. Rev. Neurosci. 3, 862872.
  • Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT (2006) PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. FASEB J. 20, 151153.
  • McCombs JE, Gibson EA, Palmer AE (2010) Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2 +  levels and dynamics. Mol. BioSyst. 6, 16401649.
  • Ozmen L, Albientz A, Czech C, Jacobsen H (2009) Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice. Neurodegener. Dis. 6, 2936.
  • Palmer AE, Giacomello M, Kortemme T, Hires SA, Lev-Ram V, Baker D, Tsien RY (2006) Ca2 + indicators based on computationally redesigned calmodulin-peptide pairs. Chem. Biol. 13, 521530.
  • Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F, Ozmen L, Bluethmann H, Drose S, Brandt U, Savaskan E, Czech C, Gotz J, Eckert A (2009) Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice. Proc. Natl Acad. Sci. U.S.A. 106, 2005720062.
  • Ribeiro JA, Sebastiao AM (2010) Caffeine and adenosine. J. Alzheimer’s Dis. 20 (Suppl. 1), S3S15.
  • Richards JG, Higgins GA, Ouagazzal AM, Ozmen L, Kew JN, Bohrmann B, Malherbe P, Brockhaus M, Loetscher H, Czech C, Huber G, Bluethmann H, Jacobsen H, Kemp JA (2003) PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. J. Neurosci. 23, 89899003.
  • Selkoe DJ (1998) The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol. 8, 447453.
  • Shilling D, Mak DO, Kang DE, Foskett JK (2012) Lack of evidence for presenilins as endoplasmic reticulum Ca2 + leak channels. J. Biol. Chem. PMID 2231197, 7.
  • Sisodia SS, St George-Hyslop PH (2002) gamma-Secretase, Notch, Abeta and Alzheimer’s disease: where do the presenilins fit in? Nat. Rev. Neurosci. 3, 281290.
  • Smith IF, Hitt B, Green KN, Oddo S, LaFerla FM (2005) Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer’s disease. J. Neurochem. 94, 17111718.
  • Stieren E, Werchan WP, El Ayadi A, Li F, Boehning D (2010) FAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis. PLoS One 5, e11992.
  • Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, Laferla F (2007) Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer’s mouse models. Ann. N.Y. Acad. Sci. 1097, 265277.
  • Swerdlow RH, Burns JM, Khan SM (2010) The Alzheimer’s disease mitochondrial cascade hypothesis. J. Alzheimers Dis. 20 (Suppl. 2), S265S279.
  • Thibault O, Gant JC, Landfield PW (2007) Expansion of the calcium hypothesis of brain aging and Alzheimer’s disease: minding the store. Aging Cell 6, 307317.
  • Thinakaran G, Sisodia SS (2006) Presenilins and Alzheimer disease: the calcium conspiracy. Nat. Neurosci. 9, 13541355.
  • Toescu EC, Verkhratsky A (2004) Ca2 + and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing. J. Cell Mol. Med. 8, 181190.
  • Toescu EC, Verkhratsky A (2007) The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging. Aging Cell 6, 267273.
  • Toescu EC, Vreugdenhil M (2010) Calcium and normal brain ageing. Cell Calcium 47, 158164.
  • Zampese E, Fasolato C, Kipanyula MJ, Bortolozzi M, Pozzan T, Pizzo P (2011) Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2 + cross-talk. Proc. Natl Acad. Sci. U.S.A. 108, 27772782.
  • Zatti G, Ghidoni R, Barbiero L, Binetti G, Pozzan T, Fasolato C, Pizzo P (2004) The presenilin 2 M239I mutation associated with familial Alzheimer’s disease reduces Ca2 + release from intracellular stores. Neurobiol. Dis. 15, 269278.
  • Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C (2006) Presenilin mutations linked to familial Alzheimer’s disease reduce endoplasmic reticulum and Golgi apparatus calcium levels. Cell Calcium 39, 539550.