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Fig. S1 Age-distribution for the samples used in this study.

Fig. S2 Sexually dimorphic expression patterns in PCG, HC and EC.

Fig. S3 Two main time-shift patterns among the SFG female-accelerated genes.

Fig. S4 Expression patterns of SFG female-accelerated gene clusters in three additional datasets.

Fig. S5 Cell type over-representation among the SFG female-accelerated gene clusters.

Fig. S6 Expression patterns for 324 female-accelerated genes in PCG.

Fig. S7 Expression patterns of SFG female-accelerated gene clusters in development and aging.

Fig. S8 Clustering of individuals reveals subgrouping within females.

Fig. S9 Sexual dimorphism in NPY and NPYR expression.

Fig. S10 A.D. effect size for sexually dimorphic genes in HC.

Fig. S11 Male-female expression distances in faster aging and slower aging females.

Fig. S12 Number of genes showing significant sexual heterochrony in four brain regions.

Table S1 Datasets used in the study.

Table S2 Sexual heterochrony across the four brain regions.

Table S3 Gene names for the four female-accelerated clusters in the superior frontal gyrus (SFG).

Table S4 Biological processes over-represented among female-accelerated genes in the superior frontal gyrus (SFG).

Table S5 Biological processes over-represented among female-accelerated genes in the postcentral gyrus (PCG).

Data S1 Xxxxx.

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