These authors contributed equally to the study.
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
Article first published online: 12 SEP 2012
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 6, pages 996–1004, December 2012
How to Cite
Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K. and von Zglinicki, T. (2012), Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell, 11: 996–1004. doi: 10.1111/j.1474-9726.2012.00870.x
Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms
- Issue published online: 15 NOV 2012
- Article first published online: 12 SEP 2012
- Accepted manuscript online: 9 AUG 2012 10:00AM EST
- Accepted for publication 31 July 2012
Fig S1 Further DDR markers in Purkinje neurons from old mice.
Fig S2 Negative controls for immunofluorescence and immunohistochemistry.
Fig S3 Purkinje neurons in old mice are positive for multiple markers of the senescent phenotype as shown by immunohistochemistry.
Fig S4 Cortical neurons in old mice are positive for multiple markers of the senescent phenotype as shown by immunohistochemistry.
Fig S5 Markers of a senescence-like phenotype in hippocampal neurons.
Fig S6 Protein oxidation increases in old mice brains.
Fig S7 The same cells are positive for multiple markers of the senescent phenotype.
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