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Fig S1 Further DDR markers in Purkinje neurons from old mice.

Fig S2 Negative controls for immunofluorescence and immunohistochemistry.

Fig S3 Purkinje neurons in old mice are positive for multiple markers of the senescent phenotype as shown by immunohistochemistry.

Fig S4 Cortical neurons in old mice are positive for multiple markers of the senescent phenotype as shown by immunohistochemistry.

Fig S5 Markers of a senescence-like phenotype in hippocampal neurons.

Fig S6 Protein oxidation increases in old mice brains.

Fig S7 The same cells are positive for multiple markers of the senescent phenotype.

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