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Review: a meta-analysis of GWAS and age-associated diseases
Article first published online: 30 AUG 2012
DOI: 10.1111/j.1474-9726.2012.00871.x
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Additional Information
How to Cite
Jeck, W. R., Siebold, A. P. and Sharpless, N. E. (2012), Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell, 11: 727–731. doi: 10.1111/j.1474-9726.2012.00871.x
Publication History
- Issue published online: 16 SEP 2012
- Article first published online: 30 AUG 2012
- Accepted manuscript online: 13 AUG 2012 10:14AM EST
- Accepted for publication 8 August 2012
References
- , , (2008) Genetic mapping in human disease. Science 322, 881–888.
- (2012) Telomerase and idiopathic pulmonary fibrosis. Mutat. Res. 730, 52–58.
- , , , , , , , , , , , , (2007) Telomerase mutations in families with idiopathic pulmonary fibrosis. New Eng. J. Med. 356, 1317–1326.
- , , , , , , , (2011) Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236.
- , , , , , , , , (2011) PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. Nature 478, 349–355.
- , , , , , , , (2008) Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet. 4, e1000024.
- , , , , , , , , , , (2011) 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response. Nature 470, 264–268.
- , (2009) Short telomeres resulting from heritable mutations in the telomerase reverse transcriptase gene predispose for a variety of malignancies. Ann. N. Y. Acad. Sci. 1176, 178–190.
- , (European Bioinformatics Institute), , , , , . A catalog of published genome-wide association studies. URL http://www.genome.gov/gwastudies [accessed on 29 June 2011].
- , , , , , , (2010) Accounting for multiple comparisons in a genome-wide association study (GWAS). BMC Genomics 11, 724.
- , , , , , (2009) Hypothesis- driven candidate gene association studies: practical design and analytical considerations. Am. J. Epidemiol. 170, 986–993.
- , , , , , , (2006) p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443, 453–457.
- , , , , , , , , , , , (2011) Cdkn2a Is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation. Arterioscler. Thromb. Vasc. Biol. 31, 2483–2492.
- , , , , , , , , (2009) INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS ONE 4, e5027.
- , , , , , , (2011) Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood 117, 3257–3267.
- , (2011) Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat. Rev. Cancer 11, 161–176.
- , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , (2008) Lung cancer susceptibility locus at 5p15.33. Nat. Genet. 40, 1404–1406.
- , , , , , , , , , , , , , , , , (2009) Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8, 460–472.
- , , , , , , , , , , , , , , , , , , , , , , , , , , , (2009) Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 106, 18680–18685.
- , , (2012) Naive Bayesian classifier and genetic risk score for genetic risk prediction of a categorical trait: not so different after all!. Front. Genet. 3, 26.
- , (2007) How stem cells age and why this makes us grow old. Nat. Rev. Mol. Cell Biol. 8, 703–713.
- , , , , , , , (2008) Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A 105, 3438–3442.
- , , , , , , , , (2007) Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A 104, 7552–7557.
- , , , , , , , (2010) Telomere length and risk of incident cancer and cancer mortality. JAMA 304, 69–75.
- , , , , , , , , , , (2008) Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3. Ann. Hum. Genet. 72, 725–731.

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