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Innate immunity in aging: impact on macrophage function

  1. Julie Plowden,
  2. Mary Renshaw-Hoelscher,
  3. Carrie Engleman,
  4. Jacqueline Katz,
  5. Suryaprakash Sambhara*

Article first published online: 25 JUN 2004

DOI: 10.1111/j.1474-9728.2004.00102.x

Issue

Aging Cell

Aging Cell

Volume 3, Issue 4, pages 161–167, August 2004

Additional Information

How to Cite

Plowden, J., Renshaw-Hoelscher, M., Engleman, C., Katz, J. and Sambhara, S. (2004), Innate immunity in aging: impact on macrophage function. Aging Cell, 3: 161–167. doi: 10.1111/j.1474-9728.2004.00102.x

Author Information

  1. Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA

*Suryaprakash Sambhara, Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333 USA. Fax: +1 404 639 3800; e-mail: ssambhara@cdc.gov

Publication History

  1. Issue published online: 9 JUL 2004
  2. Article first published online: 25 JUN 2004
  3. Accepted for publication 21 May 2004

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Keywords:

  • aging;
  • cytokines;
  • immunity;
  • inflammation;
  • macrophage;
  • wound healing

Summary

Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as ‘pathogen sensors’ and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

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