Contrast media inhibit exogenous surfactant therapy in rats with acute respiratory distress syndrome
Article first published online: 23 FEB 2006
Clinical Physiology and Functional Imaging
Volume 26, Issue 2, pages 120–126, March 2006
How to Cite
Kesecioglu, J., Haitsma, J. J., Schultz, M. J., den Heeten, G. J. and Lachmann, B. (2006), Contrast media inhibit exogenous surfactant therapy in rats with acute respiratory distress syndrome. Clinical Physiology and Functional Imaging, 26: 120–126. doi: 10.1111/j.1475-097X.2006.00659.x
- Issue published online: 23 FEB 2006
- Article first published online: 23 FEB 2006
- Accepted for publication Received 22 July 2005; accepted 21 November 2005
- contrast media;
- exogenous surfactant;
- lung lavage;
- lung mechanics;
- respiratory distress;
- surface tension
Aim: To test the effects of various contrast media on the pulmonary surfactant system.
Material and methods: In a rat model of acute respiratory distress syndrome (ARDS) induced by lung lavage, the effects of surfactant suspended in saline were compared with surfactant suspended in the contrast media Visipaque®, Gastrografin®, Omnipaque®, Telebrix M®, Telebrix® and Hexabrix®, to establish their influence on oxygenation and lung mechanics.
Results: After the induction of ARDS, surfactant instillation improved oxygenation, total lung capacity (TLC35), volume at 5 cm H2O end-expiration (V5) and Gruenwald index. The effects of Visipaque® and Gastrografin® were comparable with those of surfactant alone from 90 min onwards and at 120 min, respectively. Surfactant suspended in the other contrast media resulted in significantly lower values in the above-mentioned parameters. Surface tension was lowest in surfactant suspended in saline alone. Surfactant suspended in Visipaque® and Gastrografin® had lower surface tension compared with surfactant suspended in the other contrast media.
Conclusion: The ionic and non-ionic contrast media used in this study, cause an impairment of the physico-chemical behaviour of exogenous surfactant. Therefore, these contrast media cannot be regarded as safe in case of accidental exposure.