Hepatitis C virus infection and risk of coronary artery disease: a systematic review of the literature
Article first published online: 30 JUL 2012
© 2012 The Authors Clinical Physiology and Functional Imaging © 2012 Scandinavian Society of Clinical Physiology and Nuclear Medicine
Clinical Physiology and Functional Imaging
Volume 32, Issue 6, pages 421–430, November 2012
How to Cite
Roed, T., Lebech, A.-M., Kjaer, A. and Weis, N. (2012), Hepatitis C virus infection and risk of coronary artery disease: a systematic review of the literature. Clinical Physiology and Functional Imaging, 32: 421–430. doi: 10.1111/j.1475-097X.2012.01152.x
- Issue published online: 3 OCT 2012
- Article first published online: 30 JUL 2012
- Manuscript Accepted: 25 JUN 2012
- Manuscript Received: 14 APR 2012
- A.P. Møller Foundation for the Advancement of Medical Science
- chronic hepatitis C;
- coronary artery disease;
- ischemic heart disease;
- cardiovascular disease;
Several chronic infections have been associated with cardiovascular diseases, including Chlamydia pneumoniae, human immunodeficiency virus and viral hepatitis. This review evaluates the literature on the association between chronic hepatitis C virus (HCV) infection and the risk of coronary artery disease (CAD).
Studies were identified using several databases. Only studies on CAD in patients with HCV infection were included. A set of criteria for evaluating potential biases was made, based on known confounders and biases in observational research. Data were not synthesized because of the large heterogeneity in the included studies.
Twelve eligible references were identified. Nine did not comply with our criteria of minimizing bias, and six studies were evaluated as potentially heavily biased. The studies of the highest quality showed a trend towards association of HCV with CAD. Five studies showed this association (three studies significantly), while one showed that HCV was a protective factor against CAD.
Our findings suggest an increased risk of CAD in HCV-infected individuals. Further studies are needed to confirm this and to evaluate the magnitude of the association. Clinicians should be aware of this and strive to reduce CAD risk factors in patients with chronic HCV infection.