Corneal biomechanical properties measured with the Ocular Response Analyser in a myopic population
Version of Record online: 25 MAY 2011
Ophthalmic & Physiological Optics © 2011 The College of Optometrists
Ophthalmic and Physiological Optics
Volume 31, Issue 4, pages 404–412, July 2011
How to Cite
Plakitsi, A., O’Donnell, C., A Miranda, M., Charman, W. N. and Radhakrishnan, H. (2011), Corneal biomechanical properties measured with the Ocular Response Analyser in a myopic population. Ophthalmic and Physiological Optics, 31: 404–412. doi: 10.1111/j.1475-1313.2011.00852.x
- Issue online: 13 JUN 2011
- Version of Record online: 25 MAY 2011
- Received: 10 November 2010; Accepted: 19 April 2011
- corneal biomechanics;
- corneal hysteresis;
- corneal resistance factor;
- corneal thickness;
- intraocular pressure;
- ocular response analyser
Citation information: Plakitsi A, O’Donnell C, Miranda MA, Charman WN & Radhakrishnan H. Corneal biomechanical properties measured with the Ocular Response Analyser in a myopic population. Ophthalmic Physiol Opt 2011, 31, 404–412. doi: 10.1111/j.1475-1313.2011.00852.x
Purpose: To explore the possible association between myopia and corneal biomechanical properties in a Caucasian population, and the correlations between the properties of right and left eyes.
Methods: Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using the Ocular Response Analyser (ORA) in both eyes of 95 normal adult subjects aged between 19 and 48 years. The spherical equivalent refractive errors of the participants ranged from 0.25 to −14.00 D. The mean CH and CRF values for the right and left eyes were recorded for each subject. CH and CRF data were compared between different refractive groups.
Results: CH was found to be slightly lower in high myopes (>−6.00 D, mean CH 10.0 ± 1.2 mmHg) in comparison to moderate myopes (>−3.00 to −6.00 D, 10.1 ± 1.4 mmHg) and emmetropes and low myopes (+0.25 to −2.75 D, 10.9 ± 1.5 mmHg). The decrease in CH with the degree of myopia was about 0.13 mmHg per D or roughly 1% per D (r2 = 0.084, p < 0.001). Inter-subject variations were much greater than any systematic changes. CRF was not correlated with refractive error (r2 = 0.001, p = 0.66). Although the refractive error was highly correlated between the two eyes (r2 = 0.89, p < 0.001), CH and CRF showed a lower inter-ocular correlation (r2 = 0.68, p < 0.001 and r2 = 0.77, p < 0.001 respectively).
Conclusions: These findings may indicate that the viscoelastic properties of the cornea are altered to a minor extent in myopia. However, in this normal population, any overall systematic changes in CH and CRF with refractive error were small in comparison with the considerable inter-subject scatter at any level of refraction.