Preventive HIV Vaccine Acceptability and Behavioral Risk Compensation among a Random Sample of High-Risk Adults in Los Angeles (LA VOICES)

Authors

  • Peter A. Newman,

    1. Centre for Applied Social Research, Factor-Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street West, Toronto, ON, Canada M5S 1A1,
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    • Address correspondence to Peter A. Newman, Ph.D., Centre for Applied Social Research, Factor-Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street West, Toronto, ON, Canada M5S 1A1; e-mail: p.newman@utoronto.ca. Sung-Jae Lee, Ph.D., is with the Center for Community Health, University of California, Los Angeles, CA. Naihua Duan, Ph.D., is with the Departments of Psychiatry and Biostatistics, Columbia University, and the Division of Biostatistics, NYS Psychiatric Institute. Ellen Rudy, Ph.D., is with the Los Angeles County Department of Health Services, Sexually Transmitted Disease Program, Los Angeles, CA. Terry K. Nakazono, M.A., is with the Department of Health Services, UCLA School of Medicine, Los Angeles, CA. John Boscardin, Ph.D., is with the Department of Biostatistics & Center for AIDS Research, UCLA, Los Angeles, CA. Lisa Kakinami, Ph.D. (cand.), is with the School of Public Health, University of Rochester, Rochester, NY. Steven Shoptaw, Ph.D., is with the UCLA Department of Family Medicine, Los Angeles, CA. Allison Diamant, M.D., and William E. Cunningham, M.D., M.P.H., are with the Department of Health Services, UCLA School of Medicine, Los Angeles, CA.

  • Sung-Jae Lee,

    1. Center for Community Health, University of California, Los Angeles, CA,
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  • Naihua Duan,

    1. Departments of Psychiatry and Biostatistics, Columbia University, and the Division of Biostatistics, NYS Psychiatric Institute,
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  • Ellen Rudy,

    1. Los Angeles County Department of Health Services, Sexually Transmitted Disease Program, Los Angeles, CA,
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  • Terry K. Nakazono,

    1. Department of Health Services, UCLA School of Medicine, Los Angeles, CA,
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  • John Boscardin,

    1. Department of Biostatistics & Center for AIDS Research, UCLA, Los Angeles, CA,
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  • Lisa Kakinami,

    1. School of Public Health, University of Rochester, Rochester, NY,
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  • Steven Shoptaw,

    1. UCLA Department of Family Medicine, Los Angeles, CA,
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  • Allison Diamant,

    1. Department of Health Services, UCLA School of Medicine, Los Angeles, CA
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  • William E. Cunningham

    1. Department of Health Services, UCLA School of Medicine, Los Angeles, CA
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Abstract

Objective. To assess HIV vaccine acceptability among high-risk adults in Los Angeles.

Study Setting. Sexually transmitted disease clinics, needle/syringe exchange programs, Latino community health/HIV prevention programs.

Study Design. Cross-sectional survey using conjoint analysis. Participants were randomly selected using three-stage probability sampling.

Data Collection. Sixty-minute structured interviews. Participants rated acceptability of eight hypothetical vaccines, each with seven dichotomous attributes, and reported post-vaccination risk behavior intentions.

Principal Findings. Participants (n=1164; 55.7 percent male, 82.4 percent ethnic minority, mean age=37.4 years) rated HIV vaccine acceptability from 28.4 to 88.6; mean=54.5 (SD=18.8; 100-point scale). Efficacy had the greatest impact on acceptability, followed by side effects and out-of-pocket cost. Ten percent would decrease condom use after vaccination.

Conclusions. Findings support development of social marketing interventions to increase acceptability of “partial efficacy” vaccines, behavioral interventions to mitigate risk compensation, and targeted cost subsidies.

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