This investigation examined the influence of a prior social support interaction on a subsequent interaction between new peer acquaintances. Pairs of adolescent peers (recruited in a large metropolitan area in the United States) were videotaped as they met and discussed current life concerns in 2 separate interactions. Results indicated that (a) the behaviors of new interaction partners are coordinated within an interaction (social coordination hypothesis), (b) behaviors exhibited during an initial interaction predict behaviors exhibited during a subsequent interaction (influential interaction hypothesis), (c) individuals affiliate in similar ways across interactions (cross-situational consistency hypothesis), and (d) behaviors reflecting greater comfort with interaction increase across interactions (uncertainty reduction hypothesis). The discussion focuses on implications of results and contributions to existing literatures.