According to the risk regulation model (S. L. Murray, J. G. Holmes, & N. L. Collins, 2006), people need to trust in their partner's regard before they risk interdependence. This study prospectively examines the association between perceived regard and levels of dependence in newlywed couples over 9 years of marriage. Analyses demonstrate that changes in perceived regard predict levels of dependence, changes in dependence do not predict perceived regard, and alternative explanations cannot account for these effects. Further, changes in perceived regard prospectively predict divorce, and levels of dependence mediate this association. Results are discussed in terms of the dependence regulation component of the risk regulation model.