objective:To demonstrate the range of toxicities with 5-Fluorouracil (5-FU).
Case Summary:A one-year-old male castrated Labrador Retriever presented to the University of Minnesota Veterinary Teaching Hospital Emergency Service following accidental ingestion of a 5% 5-Fluorouracil (5-FU) topical antineoplastic cream. The animal presented with status epilepticus and later demonstrated additional clinical signs consistent with 5-FU toxicosis including mucositis and diarrhea, profound but transient leukopenia, and thrombocytopenia.
New Information Provided:The calculated ingested dosage was 46 mg/kg. The dog responded well to intensive therapy, recovering uneventfully.