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Suspected toxicosis after topical administration of minoxidil in 2 cats

Authors

  • Camille DeClementi VMD,

    1. From the 1ASPCA Animal Poison Control Center, Urbana, IL, 2University of Illinois College of Veterinary Medicine, Urbana, IL, 3Biscayne Animal Hospital, North Miami, FL4Alouette Animal Hospital, Maple Ridge, BC.
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  • 1 Keith L. Bailey DVM, PhD, DACVP,

    1. From the 1ASPCA Animal Poison Control Center, Urbana, IL, 2University of Illinois College of Veterinary Medicine, Urbana, IL, 3Biscayne Animal Hospital, North Miami, FL4Alouette Animal Hospital, Maple Ridge, BC.
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  • 2 Spencer C. Goldstein DVM,

    1. From the 1ASPCA Animal Poison Control Center, Urbana, IL, 2University of Illinois College of Veterinary Medicine, Urbana, IL, 3Biscayne Animal Hospital, North Miami, FL4Alouette Animal Hospital, Maple Ridge, BC.
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  • and 3 Michael Scott Orser DVM 4

    1. From the 1ASPCA Animal Poison Control Center, Urbana, IL, 2University of Illinois College of Veterinary Medicine, Urbana, IL, 3Biscayne Animal Hospital, North Miami, FL4Alouette Animal Hospital, Maple Ridge, BC.
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Address correspondence and reprint requests to:
Dr. Camille DeClementi, ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, IL 61802.
E-mail: camille@apcc.aspca.org

Abstract

Objective: To discuss the clinical presentation and necropsy findings of 2 cats after topical administration of a minoxidil solution. Additionally, a potential management plan is offered for future cases.

Case summary: Two cats with dermal exposure to topical minoxidil solution were identified from the ASPCA Animal Poison Control Center (APCC) files. Both cats were presented with lethargy and dyspnea within 36 hours of exposure. The cats were hypothermic, and had pulmonary edema and pleural effusion present on thoracic radiography. Both cats died despite supportive care. Necropsy of both cats confirmed pleural effusion and pulmonary edema and indicated cardiac compromise.

New or unique information provided: Topical administration of minoxidil solution may cause life-threatening pulmonary edema, pleural effusion, and cardiac dysfunction in the cat.

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