SEARCH

SEARCH BY CITATION

Our laboratory developed a customized solution containing various free-radical scavengers, energy sources, and vasodilators in an attempt to attenuate intestinal injury following an ischemic insult. This solution has been evaluated with beneficial effects following low flow ischemia and reperfusion using in vitro and in vivo models using intra-arterial and intraluminal administration. In both investigations, the solution minimized morphologic injury and decreased transmucosal leakage of albumin.

Objective: To determine if the systemic administration of the solution (GI Boost) had any clinical effect on normal horses, and to summarize the outcome of horses undergoing colic surgery that received the solution intravenously and intraluminally.

Animals: 5 healthy adult horses and at the time of submission the outcomes of 10 horses undergoing abdominal surgery for colic.

Methods: 2 L of GI Boost was administered at concentrations of 25%, 50%, and 75% intravenously (IV) to 5 normal horses. Parameters evaluated included CBC, chemistry panel, blood pressure, and physical examination. In 10 clinical cases, GI Boost was administered IV (intra-op and post-op) and intraluminally via the enterotomy.

Results: The administration of GI Boost did not produce any clinical or hematologic abnormalities in normal cases. None of the clinical cases developed any complications associated with the use of the solution. The majority of horses were discharged from the hospital and 1 died following large colon rupture.

Clinical Relevance: The administration of GI Boost may have a beneficial effect in horses presented for colic. Additional cases continue to be acquired to determine if this solution has a beneficial effect relative to traditional methods of treatment.