The use of 25% human serum albumin: outcome and efficacy in raising serum albumin and systemic blood pressure in critically ill dogs and cats
Version of Record online: 17 JUN 2005
Journal of Veterinary Emergency and Critical Care
Volume 15, Issue 2, pages 110–118, June 2005
How to Cite
Mathews, K. A. and Barry, M. (2005), The use of 25% human serum albumin: outcome and efficacy in raising serum albumin and systemic blood pressure in critically ill dogs and cats. Journal of Veterinary Emergency and Critical Care, 15: 110–118. doi: 10.1111/j.1476-4431.2005.00141.x
- Issue online: 17 JUN 2005
- Version of Record online: 17 JUN 2005
- small animal;
Objective: To report on the use of 25% human serum albumin (25% HSA) (Plasbumin®), associated outcome, and efficacy in raising serum albumin and systemic blood pressure (BP) in critically ill dogs and cats.
Design: Retrospective clinical study.
Animals: Client-owned cats and dogs.
Interventions: Administration of 25% HSA.
Measurements and main results: The medical records of 66 animals (64 dogs, 2 cats) at the Ontario Veterinary College, which received 25% HSA (Plasbumin®) from June 1997 to December 2001 were reviewed for age, body weight, clinical problems, albumin and globulin (g/L) levels pre- and within 18-hour post-transfusion and upon discharge from hospital, total solids (TS), systolic and diastolic BP pre- and post-transfusion total volume administered, adverse reactions, blood products and synthetic colloids used, and outcome. Twenty-five percent HSA was prescribed for a range of clinical problems, which were grouped into 6 categories for analysis. The age range was 4 months–12 years and body weight range 1.4–65 kg. The maximum volume administered to any dog was 25 mL/kg, mean volume administered was 5 mL/kg, maximum volume given as a slow push or bolus was 4 mL/kg with a mean of 2 mL/kg volume. The range for a constant rate infusion (CRI) was 0.1–1.7 mL/kg/hr over 4–72 hours. Forty-seven (71%) animals survived to discharge; 11(16%) were euthanized, and 8 (12%) died. Serum albumin and TS increased significantly (P<0.0001) above pre-transfusion levels as did systolic BP (P<0.01).
Conclusions: Twenty-five percent HSA can be safely administered to critically ill animals, and an increase in albumin levels and systemic BP can be expected.