Objective: The objective of this review is to summarize what is known in human and veterinary patients regarding the potential interactions of non-steroidal anti-inflammatory drugs (NSAIDs) with clinically important drugs.
Data sources: Relevant articles as identified through searches of Medline, 1985 to present.
Human data synthesis: Hemodynamic drug interactions are most likely to cause clinically relevant problems in humans, in which NSAIDs blunt the response to anti-hypertensive agents and diuretics in patients with cardiovascular disease, or cause renal decompensation in patients with hypovolemia. In addition, NSAIDs enhance the ulcerogenic effects of glucocorticoids or other recently administered NSAIDs, and can increase bleeding from anti-coagulant drugs or from herbs with platelet inhibitory activities.
Veterinary data synthesis: Although there are numerous studies examining the safety and efficacy of various NSAIDs in healthy or arthritic dogs, there are very few studies that address the safety of these agents in veterinary patients receiving medication for other acute or chronic conditions.
Conclusions: Based upon what is known in humans, more studies are needed in veterinary patients to assess the safety of NSAIDs in those animals being treated with anti-hypertensive, diuretic or anti-coagulant drugs.