Renal hemodynamic and diuretic effects of low-dosage dopamine in anesthetized cats
Version of Record online: 26 JAN 2007
Journal of Veterinary Emergency and Critical Care
Volume 17, Issue 1, pages 45–52, March 2007
How to Cite
Wohl, J. S., Schwartz, D. D., Flournoy, W. S., Clark, T. P. and Wright, J. C. (2007), Renal hemodynamic and diuretic effects of low-dosage dopamine in anesthetized cats. Journal of Veterinary Emergency and Critical Care, 17: 45–52. doi: 10.1111/j.1476-4431.2006.00209.x
- Issue online: 26 JAN 2007
- Version of Record online: 26 JAN 2007
- renal protection;
- urine output
Objective: To evaluate the effects of low-dosage (3 μg/kg/min) dopamine on urine output, renal blood flow, creatinine clearance, sodium excretion, heart rate, and mean arterial pressure (MAP) in healthy anesthetized cats.
Design: Controlled experimental study.
Setting: University experimental laboratory.
Animals: Twelve random-bred 2–4-year-old cats.
Interventions: Anesthesia, laparotomy for renal artery blood flow measurement, and arterial and venous catheterization.
Measurements: Heart rate (HR), MAP, renal blood flow, urine output, sodium excretion, fractional sodium excretion, and creatinine clearance.
Main results: No significant difference in urine output, sodium excretion, HR, or creatinine clearance occurred in cats receiving low-dosage dopamine. A transient decrease in the mean arterial blood pressure occurred in cats receiving dopamine.
Conclusions: Low-dosage dopamine cannot be expected to induce diuresis in healthy cats. Low-dosage dopamine may cause vasodilation in non-renal vascular beds.