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Keywords:

  • diuresis;
  • dopaminergic;
  • feline;
  • renal protection;
  • urine output

Abstract

Objective: To evaluate the effects of low-dosage (3 μg/kg/min) dopamine on urine output, renal blood flow, creatinine clearance, sodium excretion, heart rate, and mean arterial pressure (MAP) in healthy anesthetized cats.

Design: Controlled experimental study.

Setting: University experimental laboratory.

Animals: Twelve random-bred 2–4-year-old cats.

Interventions: Anesthesia, laparotomy for renal artery blood flow measurement, and arterial and venous catheterization.

Measurements: Heart rate (HR), MAP, renal blood flow, urine output, sodium excretion, fractional sodium excretion, and creatinine clearance.

Main results: No significant difference in urine output, sodium excretion, HR, or creatinine clearance occurred in cats receiving low-dosage dopamine. A transient decrease in the mean arterial blood pressure occurred in cats receiving dopamine.

Conclusions: Low-dosage dopamine cannot be expected to induce diuresis in healthy cats. Low-dosage dopamine may cause vasodilation in non-renal vascular beds.