• antidiuretic hormone;
  • canine;
  • catecholamine-resistance;
  • central venous pressure;
  • heart rate;
  • hypotension;
  • mean arterial pressure


Objective: To describe the therapeutic use of vasopressin in dogs with dopamine-resistant hypotension and vasodilatory shock.

Series summary: We report the effects of intravenous vasopressin therapy on mean arterial blood pressure and central venous pressure (CVP) in 5 dogs with dopamine-resistant hypotension from vasodilatory shock. All subjects had documented hypotension and vasodilation, despite adequate intravascular volume and catecholamine therapy. There was an increase in mean arterial pressure following vasopressin administration. No cardiac arrhythmias were noted, nor were there clinically significant changes in CVP.

New information provided: Mean arterial blood pressure increased following vasopressin therapy in all of the dogs. Vasopressin may prove useful in the treatment of vasodilatory shock, however further research is warranted.