Successful cardiopulmonary resuscitation and use of short-term mechanical ventilation following inadvertent ketamine overdose in a cat
Article first published online: 29 MAR 2008
© Veterinary Emergency and Critical Care Society 2008
Journal of Veterinary Emergency and Critical Care
Volume 18, Issue 2, pages 165–169, April 2008
How to Cite
Cortés, Y. E. and Holm, J. L. (2008), Successful cardiopulmonary resuscitation and use of short-term mechanical ventilation following inadvertent ketamine overdose in a cat. Journal of Veterinary Emergency and Critical Care, 18: 165–169. doi: 10.1111/j.1476-4431.2008.00291.x
- Issue published online: 29 MAR 2008
- Article first published online: 29 MAR 2008
- anesthetic agents;
- small animal critical care
Objective: To describe the clinical manifestations and successful outcome following an inadvertent overdose of ketamine to a cat.
Case summary: A 4-year-old neutered male domestic shorthair cat was evaluated for a urethral obstruction. Because of an inadvertent miscalculation of ketamine, 20 times the intended dose was administered intravenously, which resulted in cardiopulmonary arrest. Cardiopulmonary-cerebral resuscitation was successful, and short-term mechanical ventilation, fluids and intensive monitoring were utilized to achieve full recovery and subsequent discharge of the animal.
New or unique information provided: Ketamine is a common anesthetic agent used in cats that is considered to have a wide therapeutic index and minimal cardiopulmonary depressant effects at recommended doses. Successful management of inadvertent ketamine overdose has been reported in children, but not in cats. Prompt CPCR and short-term mechanical ventilation may be necessary to treat a significant ketamine overdose. In cats, yohimbine may act as a partial antagonist of ketamine.