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A case-based review of a simplified quantitative approach to acid-base analysis

Authors

  • Kate Hopper BVSc, PhD, DACVECC,

    1. Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
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  • Steve C. Haskins DVM, DACVECC

    1. Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
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  • No reprints will be available from the author.

Address correspondence and reprint requests to
Dr. Kate Hopper, Room 2112, Tupper Hall, Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Email: khopper@ucdavis.edu

Abstract

Objective – To present a simplified quantitative approach to acid-base analysis and to demonstrate its clinical utility.

Data Sources – Original research articles and textbooks.

Data Synthesis – A simplified quantitative approach to acid-base analysis is presented, which is derived from the Fencl-Stewart approach and calculates the magnitude of the effect on the standardized base excess (SBE) of 5 separate variables: (1) a free water effect (marked by sodium concentration), (2) an effect marked by the chloride concentration, (3) an albumin effect, (4) a lactate effect, and (5) a phosphate effect. Six clinical cases with acid-base abnormalities are presented in which the quantitative approach provides information that is not apparent from the traditional approach.

Conclusion – This simplified quantitative approach provides a comprehensive evaluation of complex acid-base disorders, identifies individual processes and their relative influence on SBE, and aids in the development of an appropriate therapeutic plan.

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