• 1
    Bohm M, Leisewitz AL, Thompson PN, et al. Capillary and venous Babesia canis rossi parasitaemias and their association with outcome of infection and circulatory compromise. Vet Parasitol 2006; 141 (1–2):1829.
  • 2
    Jacobson LS. The South African form of severe and complicated canine babesiosis: clinical advances. Vet Parasitol 2006; 31:126139.
  • 3
    Shakespeare AS. The incidence of canine babesiosis amongst sick dogs presented to the Onderstepoort Veterinary Academic Hospital. J S Afr Vet Assoc 1995; 66 (4):247250.
  • 4
    Van Zyl M. Prediction of Survival in Hospitalised Cases of Canine Babesiosis: A Retrospective Investigation Employing Serum Biochemical Parameters and Signalment Data. In. Small Animal Medicine. Pretoria, South Africa: University of Pretoria; 1995.
  • 5
    Abdullahi SU, Mohammed AA, Trimnell AR, et al. Clinical and haematological findings in 87 naturally occurring cases of canine babesiosis. J Small Anim Prac 1990; 31:145147.
  • 6
    Button C. Metabolic and electrolyte disturbances in acute canine babesiosis. J Am Vet Med Assoc 1979; 175 (5):475479.
  • 7
    Leisewitz AL, Guthrie AJ, Berry WL. Evaluation of the effect of whole-blood transfusion on the oxygen status and acid-bases balance of Babesia canis infected dogs using the oxygen status algorithm. J S Afr Vet Assoc 1996; 67 (1):2026.
  • 8
    Le Roux PH. Blood transfusions in dogs and its effect in canine babesiosis. J S Afr Vet Assoc 1965; 36 (1):2122.
  • 9
    Callan MB, Rentko VT. Clinical application of a hemoglobin-based oxygen-carrying solution. Vet Clin North Am Small Anim Pract 2003; 33:12771293.
  • 10
    Katz LM, Manning JE, McCurdy S, et al. HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury. Resuscitation 2002; 54 (1):7787.
  • 11
    Knudson MM, Lee S, Erickson V, et al. Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated ringer's solution, hypertonic saline dextran, and HBOC-201. J Trauma Inj Infect Crit Care 2003; 54 (2):242252.
  • 12
    Levy JH, Goodnough LT, Greilich PE, et al. Polymerised bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomised, double-blind trial. J Thorac Cardiovasc Surg 2002; 124 (1):3542.
  • 13
    Driessen B, Jahr JS, Lurie F, et al. Inadequacy of low-volume resuscitation with haemoglobin-based carrier haemoglobin glutamer-200 (bovine) in canine hypovolaemia. J Vet Ther 2001; 24:6171.
  • 14
    Gibson GR, Callan MB, Hoffman V, et al. Use of a hemoglobin-based oxygen-carrying solution in cats: 72 cases (1998–2000). J Am Vet Med Assoc 2002; 221 (1):96102.
  • 15
    Grundy SA, Barton C. Influence of drug treatment on survival of dogs with immune-mediated hemolytic anaemia: 88 cases (1989–1999). J Am Vet Med Assoc 2001; 218 (4):543546.
  • 16
    Rohlfs RJ, Bruner E, Chiu A, et al. Arterial blood pressure responses to cell-free haemoglobin solutions and the reaction with nitric oxide. J Biol Chem 1998; 273:1212812134.
  • 17
    Day TK, Macintire DK, Murtaugh RJ, et al. Differing opinions on treatment of immune-mediated haemolytic anaemia. J Am Vet Med Assoc 2001; 218 (9):1414.
  • 18
    Hamilton RG, Kelly N, Hawryl MS, et al. Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs. Transfusion 2001; 41:219225.
  • 19
    Hamilton RG, Kickler TS. Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro. Transfusion 2007; 47 (4):723728.
  • 20
    Collett MG. Survey of canine babesiosis in South Africa, In: LewisBDJ, LS. eds. Proceedings of a Symposium on Canine Babesiosis. Pretoria: University of Pretoria; 1995, pp. 1318.
  • 21
    Leisewitz AL, Jacobson LS, De Morais HSA, et al. The mixed acid-based disturbances of severe canine babesiosis. J Vet Intern Med 2001; 15:445452.
  • 22
    De Morais HA, Leisewitz AL. Mixed acid-base disorders, In: Di BartolaSP. ed. Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice, 3rd ed. St Louis: Saunders Elsevier; 2006, pp. 296309.
  • 23
    Whitehair KJ, Haskins SC, Whitehair JG, et al. Clinical applications of quantitative acid-base chemistry. J Vet Intern Med 1995; 9:111.
  • 24
    Matjila PT, Penzhorn BL, Bekker CPJ, et al. Confirmation of occurence of Babesia canis vogeli in domestic dogs in South Africa. Vet Parasitol 2004; 122:119125.
  • 25
    Reyers F, Leisewitz AL, Lobetti RG, et al. Canine babesiosis in South Africa: more than one disease. Does this serve as a model for Falciparum malaria? Ann Trop Med Parasitol 1998; 92 (4):503511.
  • 26
    Schetters TPM, Eling WMC. Can babesia infections be used as a model for cerebral malaria? Parasitol Today 1999; 15 (12):492497.
  • 27
    Button C. Fluid therapy in canine babesiosis. J S Afr Vet Assoc 1976; 47:284287.
  • 28
    Siggaard-Andersen M, Fogh-Andersen N. Base excess of buffer base (strong ion difference) as a measure of a non-respiratory acid-base disturbance. Acta Anaesthiologica Scandanavica 1995; 39 (suppl 107):123128.
  • 29
    Lòpez-Barneo J, Pardal R, Ortega-Sàenz P. Cellular mechanisms of oxygen sensing. Ann Rev Physiol 2001; 63:259287.
  • 30
    Malherbe WD, Immelman A, Haupt WH, et al. The diagnosis and treatment of acid-base deranged dogs infected with Babesia canis. J S Afr Vet Assoc 1976; 47 (1):2933.
  • 31
    Weil MH, Rackow EC, Trevino R, et al. Difference in acid-base state between venous and arterial blood during cardiopulmonary resuscitation. N Engl J Med 1986; 315 (3):153156.
  • 32
    Siggaard-Andersen O, Wimberley PD, Fogh-Andersen N, et al. Arterial oxygen status determined with routine pH/blood gas equipment and multi-wavelength hemoximetry: reference values, precision and accuracy. Scand J Clin Lab Invest 1990; 50 (suppl 203):5766.
  • 33
    Igarashi I, Aikawa M, Kreier JP. Host cell-parasite interaction in babesiosis, In: RisticM. ed. Babesiosis of Domestic Animals and Man. Boca Raton: CRC Press; 1988, pp. 5369.
  • 34
    Ilkiw JE, Rose RJ, Martin ICA. A comparison of simultaneously collected arterial, mixed venous, jugular venous and cephalic venous blood samples in the assessment of blood-gas and acid-base status in the dog. J Vet Intern Med 1991; 5:294298.
  • 35
    Rodkey WG, Hannon JP, Dramise JG, et al. Arterialized capillary blood used to determine the acid-base and blood gas status of dogs. Am J Vet Res 1978; 39 (3):459464.
  • 36
    Kellum HA, Kramer DJ, Pinsky MR. Strong ion gap: a methodology for exploring unexplained anions. J Crit Care 1995; 10:5155.
  • 37
    Lobetti RG, Mohr AJ, Dippenaar T, et al. A preliminary study on the serum protein response in canine babesiosis. J S Afr Vet Assoc 2000; 71 (1):3842.
  • 38
    De Morais HA, Constable PD. Strong ion approach to acid-base disorders, In: Di BartolaSP. ed. Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice, 3rd ed. St Louis: Saunders Elsevier; 2006, pp. 310321.
  • 39
    Jacobson LS, Lobetti R. Glucose, lactate, and pyruvate concentrations in dogs with babesiosis. Am J Vet Res 2005; 66 (2):244250.
  • 40
    Nel M, Lobetti RG, Keller N, et al. Prognostic value of blood lactate, blood glucose and hematocrit in canine babesiosis. J Vet Int Med 2004; 18:471476.
  • 41
    Welzl C, Leisewitz AL, Jacobson LS, et al. Systemic inflammatory response syndrome and multiple organ damage/dysfunction in complicated canine babesiosis. J S Afr Vet Assoc 2001; 72 (3):158162.
  • 42
    Vaughn-Scott T. Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia canis and its relation to severity of disease. Thesis dissertation. Department of Small Animal Medicine, Faculty of Veterinary Science, University of Pretoria, South Africa: Pretoria; 1998.
  • 43
    Jacobson LS, Lobetti RG, Becker P, et al. Nitric oxide metabolites in naturally occurring canine babesiosis. Vet Parasitol 2002; 104 (1):2741.
  • 44
    Soloviev MV, Hamlin RL, Shellhammer LJ, et al. Variations in hemodynamic parameters and ECG in healthy, conscious, freely moving telemetrized beagle dogs. Cardiovasc Toxicol 2006; 6 (1):5162.
  • 45
    Jacobson LS, Lobetti RG, Vaughan-Scott T. Blood pressure changes in dogs with babesiosis. J S Afr Vet Assoc 2000; 71:1420.
  • 46
    Sharma A, Singh G, Gulati A. Role of NO mechanism in cardiovascular effects of DCLHb in anesthetized rates. Am J Physiol 1995; 269:H1379H1388.
  • 47
    Schultz S, Grady B, Cole F, et al. A role for endothelium in the pressor response to DCLHb. J Lab Clinic Med 1993; 122:301308.