The cell-based model of coagulation
Article first published online: 27 FEB 2009
© Veterinary Emergency and Critical Care Society 2009
Journal of Veterinary Emergency and Critical Care
Volume 19, Issue 1, pages 3–10, February 2009
How to Cite
Smith, S. A. (2009), The cell-based model of coagulation. Journal of Veterinary Emergency and Critical Care, 19: 3–10. doi: 10.1111/j.1476-4431.2009.00389.x
- Issue published online: 27 FEB 2009
- Article first published online: 27 FEB 2009
- procoagulant membrane;
Objective – To review the current model describing coagulation processes, including the critical contributions of cells.
Data Sources – Original research articles, scientific reviews, and textbooks.
Data Synthesis – Normal hemostasis is vital for prevention of blood loss, but controls are necessary to limit coagulation to the site of injury. The previous cascade model of blood coagulation, although refined and updated over the last few decades, is flawed as a description of how hemostasis occurs in vivo. The recently proposed model incorporates the vital role of cells in coagulation processes, and corrects deficiencies of the older cascade models.
Conclusions – The cell-based model of coagulation provides a description of coagulation that more likely reflects hemostatic processes as they occur in vivo.