Factor VIII inhibitors complicating treatment of postoperative bleeding in a dog with hemophilia A
Version of Record online: 22 JUL 2009
© Veterinary Emergency and Critical Care Society 2009
Journal of Veterinary Emergency and Critical Care
Volume 19, Issue 4, pages 381–385, August 2009
How to Cite
O'Kelley, B. M., Whelan, M. F. and Brooks, M. B. (2009), Factor VIII inhibitors complicating treatment of postoperative bleeding in a dog with hemophilia A. Journal of Veterinary Emergency and Critical Care, 19: 381–385. doi: 10.1111/j.1476-4431.2009.00437.x
- Issue online: 12 AUG 2009
- Version of Record online: 22 JUL 2009
- transfusion medicine
Objective – To describe the clinical course of a dog with hemophilia A and circulating factor VIII inhibitors complicating the treatment of postoperative hemorrhage.
Case Summary – A 7-year-old castrated male Japanese Chin with hemophilia A, weighing 6 kg, was presented for dental cleaning, polishing, and extractions. Despite presurgical administration of cryoprecipitate, continuous oral bleeding occurred. Circulating factor VIII inhibitors were detected, and the postoperative hemorrhage was subsequently managed with extensive and prolonged blood component transfusion. The dog was discharged after a full clinical recovery.
New or Unique Information Provided – This case report describes the clinical consequences and successful treatment of postoperative hemorrhage in a dog with hemophilia A and circulating factor VIII inhibitors. A relevant discussion of the management of human patients with circulating factor VIII inhibitors is included.