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The effect of Hetastarch (670/0.75) in vivo on platelet closure time in the dog

  1. Lisa Smart BVSc, DACVECC1,5,6,
  2. Karl E. Jandrey DVM, DACVECC2,
  3. Philip H. Kass DVM, PhD, DACVPM3,
  4. Janelle R. Wierenga DVM, DACVECC1,
  5. Fern Tablin VMD, PhD4

Article first published online: 11 SEP 2009

DOI: 10.1111/j.1476-4431.2009.00464.x

Issue

Journal of Veterinary Emergency and Critical Care

Journal of Veterinary Emergency and Critical Care

Volume 19, Issue 5, pages 444–449, October 2009

Additional Information

How to Cite

Smart, L., Jandrey, K. E., Kass, P. H., Wierenga, J. R. and Tablin, F. (2009), The effect of Hetastarch (670/0.75) in vivo on platelet closure time in the dog. Journal of Veterinary Emergency and Critical Care, 19: 444–449. doi: 10.1111/j.1476-4431.2009.00464.x

Author Information

  1. 1

    William R. Pritchard Veterinary Medical Teaching Hospital,

  2. 2

    the Departments of Veterinary Surgical and Radiological Sciences,

  3. 3

    Population Health and Reproduction, and

  4. 4

    Anatomy, Physiology and Cell Biology,

  5. 5

    School of Veterinary Medicine, University of California, Davis, Davis, CA 95616

  6. 6

    the School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia

*Address correspondence and reprint requests to Dr. Lisa Smart, School of Veterinary and Biomedical Science, Murdoch University, South St, Murdoch, WA 6150, Australia.Email: l.smart@murdoch.edu.au

  1. Study funded by the University of California, Davis, Small Animal Emergency and Critical Care Service.

  2. Presented in abstract form at the American College of Veterinary Internal Medicine Forum, San Antonio, TX, 2008. The authors declare no conflicts of interest.

Publication History

  1. Issue published online: 7 OCT 2009
  2. Article first published online: 11 SEP 2009

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Keywords:

  • artificial colloid;
  • canine;
  • closure time;
  • coagulopathy;
  • hydroxyethyl starch

Abstract

Objective – To evaluate the effect of 6% hydroxyethyl starch (HES) solution in vivo, with an average molecular weight of 670 kDa and degree of substitution of 0.75, on canine platelet function.

Design – Prospective, controlled-experimental study.

Setting – University of California, Davis, Veterinary Medical Teaching Hospital.

Animals – Seven healthy employee-owned dogs.

Interventions – Seven dogs were included in the treatment group. Four of these dogs also served as the control group. Platelet closure time (CT) was measured using a platelet function analyzer and collagen/ADP cartridges. Dogs were given 20 mL/kg of either sodium chloride 0.9% (control group, n=4) or HES (treatment group, n=7) IV over 1 hour. CT was measured before the infusion, and at 1, 3, 5, and 24 hours after the start of the infusion.

Measurements and Main Results – There was a significant change over time from 0 to 24 hours (P<0.001), a significant difference between groups across time (P<0.001), and a significant group-by-time interaction (P=0.007). At 3 hours, mean CT for the treatment group was 122.3±18.1 seconds, which was significantly different (P<0.001) from the control group (71.0±3.5 s). At 5 hours, mean CT for the treatment group was 142.7±33.9 seconds, which was significantly different (P=0.001) from the control group (75.0±8.6 s). Mean CT at 24 hours was within the reference interval for both the control and treatment group (66.0±2.9 and 81.8±11.9 s, respectively); however, CT in 3 individual dogs in the treatment group at this time point remained prolonged.

Conclusions – A clinically relevant dose of HES 670/0.75 prolongs CT in dogs for up to 24 hours. This may be due to platelet dysfunction in addition to the effects of hemodilution, and therefore, may increase the risk of bleeding.

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