Dr. Holahan current address: The College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823, USA.
Retrospective Study: The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003–2006)
Article first published online: 21 JUN 2010
© Veterinary Emergency and Critical Care Society 2010
Journal of Veterinary Emergency and Critical Care
Volume 20, Issue 4, pages 413–420, August 2010
How to Cite
Holahan, M. L., Brown, A. J. and Drobatz, K. J. (2010), Retrospective Study: The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003–2006). Journal of Veterinary Emergency and Critical Care, 20: 413–420. doi: 10.1111/j.1476-4431.2010.00551.x
Presented in part at the International Veterinary Emergency and Critical Care Symposium, Phoenix, AZ, September 2008.
- Issue published online: 23 AUG 2010
- Article first published online: 21 JUN 2010
- Submitted August 1, 2009; Accepted May 19, 2010.
- illness severity;
- lactate clearance;
- prognostic indicators
Objective – To determine the association of blood lactate with outcome and response to transfusion therapy in dogs with idiopathic immune-mediated hemolytic anemia (IMHA).
Design – Retrospective study.
Setting – Urban veterinary small animal emergency hospital.
Animals – One hundred and seventy-three client-owned dogs with IMHA.
Interventions – None.
Measurements and Main Results – Serial blood lactate concentration, therapeutic interventions, and outcome were recorded. Nonsurvivors were defined as those that died or were euthanized. One hundred and thirty-three dogs (77%) survived, 35 (20%) were euthanized, and 5 (3%) died. One hundred forty-five dogs (84%; 145/173) had a lactate concentration above the laboratory reference interval [0.46–2.31 mmol/L] on presentation. Blood lactate at presentation was higher in the nonsurvivors (median 4.8 mmol/L; 0.5–13.6) compared with survivors (median 2.9 mmol/L; 0.3–13.2) (P<0.01). All dogs presenting with hyperlactatemia that normalized (<2.0 mmol/L) within 6 hours of admission survived, whereas, 71% of dogs that had a persistent hyperlactatemia at 6 hours survived (P=0.034). Lactate was positively correlated with age, BUN, and alkaline phosphatase, and inversely correlated with PCV. Receiver operating curve analysis for lactate concentration at admission as a test for outcome had an area under the curve of 0.69 with an optimal lactate cutoff concentration of 4.4 mmol/L correctly predicting outcome 73% of the time (sensitivity 60%, specificity 77%).
Conclusions – Lactate concentration at presentation was significantly higher in nonsurvivors than survivors. Lactate was significantly correlated with previously reported outcome variables but lactate concentration at admission, as a predictor for outcome was less than optimal. However, serial lactate concentration measurements may be more predictive as patients with persistent hyperlactatemia 6 hours after admission were less likely to survive. Prospective studies evaluating serial lactate concentration while controlling for other variables may provide further insight into lactate measurement as a prognostic indicator in animals with IMHA.