Data were presented at the 19th ACVS Veterinary Symposium, Washington, DC, October 2009.
Hepatic and metabolic changes in surgical colic patients: a pilot study
Article first published online: 17 DEC 2010
© Veterinary Emergency and Critical Care Society 2010
Journal of Veterinary Emergency and Critical Care
Volume 20, Issue 6, pages 578–586, December 2010
How to Cite
Underwood, C., Southwood, L. L., Walton, R. M. and Johnson, A. L. (2010), Hepatic and metabolic changes in surgical colic patients: a pilot study. Journal of Veterinary Emergency and Critical Care, 20: 578–586. doi: 10.1111/j.1476-4431.2010.00597.x
Authors declare no conflicts of interest.
- Issue published online: 17 DEC 2010
- Article first published online: 17 DEC 2010
- Submitted December 13, 2009; Accepted October 7, 2010.
- gastrointestinal surgery;
- liver enzymes;
Objective – To determine: (1) changes in blood ammonia, bile acid (BA), bilirubin, triglyceride, and glucose concentrations and liver enzyme activities in perioperative colic patients and (2) the association between these laboratory findings and short-term survival.
Design – Prospective observational clinical study.
Animals – Thirty-two adult horses undergoing exploratory celiotomy for colic.
Interventions – None.
Measurements and Main Results – Blood samples were collected preoperatively and at 24–36 and 72–84 hours postoperatively and analyzed for blood ammonia, BA, bilirubin, triglyceride, and glucose concentrations and sorbitol dehydrogenase (SDH) and gamma glutamyl transferase (GGT) activities. Short-term survival was defined as survival to hospital discharge. Data were analyzed using a Fisher's exact test and analysis of variance. Mildly increased blood ammonia concentrations were present in 2 horses at admission. Postoperative blood ammonia concentrations were within reference intervals in all horses. There were increases in liver enzyme activities as well as in BA, triglyceride, and total bilirubin concentrations. Horses with markedly increased admission BA concentrations and SDH activities did not survive. BA concentrations and SDH activities decreased postoperatively. There was no association between GGT activity and survival; GGT activity remained increased postoperatively. Blood triglyceride concentration was increased in almost all horses postoperatively; horses that did not survive had higher triglyceride concentrations at 24–36 hours postoperatively than horses that survived.
Conclusion – Alterations in metabolism and hepatobiliary function are common in colic patients. The results of this study provide further prognostic indices for colic patients and highlight areas for improvement in patient management.