The authors declare no conflict of interest.
4-Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats
Article first published online: 29 APR 2011
© Veterinary Emergency and Critical Care Society 2011
Journal of Veterinary Emergency and Critical Care
Volume 21, Issue 3, pages 268–272, June 2011
How to Cite
Tart, K. M. and Powell, L. L. (2011), 4-Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats. Journal of Veterinary Emergency and Critical Care, 21: 268–272. doi: 10.1111/j.1476-4431.2011.00638.x
- Issue published online: 1 JUN 2011
- Article first published online: 29 APR 2011
- Submitted May 13, 2010; Accepted March 23, 2011.
Objective – To describe the clinical experience and therapeutic use of fomepizole (4-methylpyrazole [4-MP]) in 3 cats with naturally occurring ethylene glycol (EG) toxicity.
Case or Series Summary – All cats were documented to be EG positive by an ethylene glycol test kit. This report describes the dose of 4-MP used, available clinicopathological data, and clinical progression during hospitalization. All patients survived to discharge.
New or Unique Information Provided – IV use of 4-MP at 125 mg/kg as an initial dose and 31.25 mg/kg at 12, 24, and 36 hours is safe and effective for treatment of naturally occurring EG toxicity in cats. Increased HCO3 concentrations were noted after IV use of 4-MP. This is the first report documenting the successful treatment of naturally occurring EG intoxication in cats with 4-MP.