The authors report no conflict of interest.
Intravenous fat emulsion as treatment for ivermectin toxicosis in three dogs homozygous for the ABCB1–1Δ gene mutation
Article first published online: 13 DEC 2011
© Veterinary Emergency and Critical Care Society 2011
Journal of Veterinary Emergency and Critical Care
Volume 21, Issue 6, pages 666–672, December 2011
How to Cite
Wright, H. M., Chen, A. V., Talcott, P. A., Poppenga, R. H. and Mealey, K. L. (2011), Intravenous fat emulsion as treatment for ivermectin toxicosis in three dogs homozygous for the ABCB1–1Δ gene mutation. Journal of Veterinary Emergency and Critical Care, 21: 666–672. doi: 10.1111/j.1476-4431.2011.00687.x
The results of this study were presented in part at the ACVIM Forum in Denver, Colorado on June 16, 2011.
- Issue published online: 13 DEC 2011
- Article first published online: 13 DEC 2011
- Manuscript Accepted: 25 SEP 2011
- Manuscript Received: 24 MAR 2011
- central nervous system depressants;
To describe the outcome of 3 cases of ivermectin toxicosis in dogs homozygous for the ABCB1–1Δ gene mutation treated with intravenous fat emulsion (IFE).
One Australian Shepherd and 2 Miniature Australian Shepherds were treated for naturally occurring ivermectin toxicosis with IFE. All 3 dogs were homozygous for the ABCB1–1Δ gene mutation. Serum ivermectin concentrations confirmed ivermectin exposure in each case. All 3 dogs exhibited tremors, ptyalism, and central nervous system depression, which progressed over several hours to stupor in 2 dogs, and to a comatose state requiring mechanical ventilation in the remaining dog. A 20% formulation of IFEa was administered as an IV bolus (1.5 mL/kg) followed by a slow IV infusion (7.5–15 mL/kg [0.25–0.5 mL/kg/m], over 30 minutes). No change was observed in the neurologic status of any patient. Lipemia visible upon blood sampling persisted for 36 hours in 1 dog however, no other adverse effects were noted. Flumazenil (0.01 mg/kg IV), followed by a constant rate infusion(CRI) of 0.01 mg/kg/h IV was administered in 1 case, without any apparent clinical benefit or adverse effect.
New or Unique Information Provided
IFE was ineffective in the treatment of ivermectin toxicosis in these ABCB1–1Δ homozygous mutant dogs. Further investigation is necessary to determine why IFE treatment was unsuccessful in these cases and whether its use can be optimized to yield better results.