Robert Goggs is supported by a Wellcome Trust research training fellowship. The British Heart Foundation, the Wellcome Trust, the Medical Research Council, and the Biotechnology and Biological Sciences Research Council support work in Prof. Alastair Poole's laboratory.
State of the Art Review
Platelet signaling–A primer
Article first published online: 3 FEB 2012
© Veterinary Emergency and Critical Care Society 2012
Journal of Veterinary Emergency and Critical Care
Volume 22, Issue 1, pages 5–29, February 2012
How to Cite
Goggs, R. and Poole, A. W. (2012), Platelet signaling–A primer. Journal of Veterinary Emergency and Critical Care, 22: 5–29. doi: 10.1111/j.1476-4431.2011.00704.x
The authors declare no conflict of interest.
- Issue published online: 17 FEB 2012
- Article first published online: 3 FEB 2012
- Manuscript Accepted: 25 NOV 2011
- Manuscript Received: 29 APR 2011
- primary hemostasis;
To review the receptors and signal transduction pathways involved in platelet plug formation and to highlight links between platelets, leukocytes, endothelium, and the coagulation system.
Original studies, review articles, and book chapters in the human and veterinary medical fields.
Platelets express numerous surface receptors. Critical among these are glycoprotein VI, the glycoprotein Ib-IX-V complex, integrin αIIbβ3, and the G-protein-coupled receptors for thrombin, ADP, and thromboxane. Activation of these receptors leads to various important functional events, in particular activation of the principal adhesion receptor αIIbβ3. Integrin activation allows binding of ligands such as fibrinogen, mediating platelet-platelet interaction in the process of aggregation. Signals activated by these receptors also couple to 3 other important functional events, secretion of granule contents, change in cell shape through cytoskeletal rearrangement, and procoagulant membrane expression. These processes generate a stable thrombus to limit blood loss and promote restoration of endothelial integrity.
Improvements in our understanding of how platelets operate through their signaling networks are critical for diagnosis of unusual primary hemostatic disorders and for rational antithrombotic drug design.