The action of antidiuretic hormone on cell membranes. Voltage transient studies
Article first published online: 19 JUL 2012
1969 British Pharmacological Society
British Journal of Pharmacology
Volume 35, Issue 1, pages 29–50, January 1969
How to Cite
CUTHBERT, A. W. and PAINTER, E. (1969), The action of antidiuretic hormone on cell membranes. Voltage transient studies. British Journal of Pharmacology, 35: 29–50. doi: 10.1111/j.1476-5381.1969.tb07965.x
- Issue published online: 19 JUL 2012
- Article first published online: 19 JUL 2012
- Received May 9, 1968
- 1The instantaneous impedance method has been used to study the effects of antidiuretic hormone (ADH) on frog skin.
- 2The resting skin may be represented by a parallel RC network with a single time constant.
- 3Antidiuretic hormone causes an increase in conductance and capacitance and in some cases the appearance of a polarization angle.
- 4The structures in the skin responsible for the transients are located in the outermost membranes.
- 5The effects of ADH have been interpreted in terms of the formation of water-filled sodium-permselective pores in the outer facing membranes which occupy, at most, 0.3% of the skin surface. These pores constitute a parallel, and hence additive, capacitance with that of the normally ion impermeable parts of the cell surface, and in addition are responsible for the increase in conductance. The polarization angle is due to the polydisperse nature of the skin after hormone treatment.