CIRCULATORY EFFECTS OF ORAL AND SUBCUTANEOUS ADMINISTRATION IN NORMAL SUBJECTS OF A NEW BRONCHODILATOR, IBUTEROL, A PRO-DRUG TO TERBUTALINE
Article first published online: 19 JUL 2012
1976 British Pharmacological Society
British Journal of Pharmacology
Volume 58, Issue 1, pages 43–46, September 1976
How to Cite
HÖGLUND, E., WESTLING, H. and WHITE, T. (1976), CIRCULATORY EFFECTS OF ORAL AND SUBCUTANEOUS ADMINISTRATION IN NORMAL SUBJECTS OF A NEW BRONCHODILATOR, IBUTEROL, A PRO-DRUG TO TERBUTALINE. British Journal of Pharmacology, 58: 43–46. doi: 10.1111/j.1476-5381.1976.tb07691.x
- Issue published online: 19 JUL 2012
- Article first published online: 19 JUL 2012
- Received October 9, 1975. Revised March 1, 1976
- 1The di-isobutyryl ester of terbutaline, ibuterol, was given subcutaneously and orally to healthy volunteers and its effects on heart rate, arterial blood pressure, and ECG were compared with those of terbutaline itself. The effects of the two substances were qualitatively identical, but quantitatively different.
- 2By mouth, ibuterol acted more rapidly, and was 2–3 times more active. After intramuscular injection, ibuterol caused less increase in local blood flow than terbutaline.
- 3Ibuterol can be regarded as a pro-drug, which in itself has little activity, but which can be made active in the body.