CANNABIS, CATECHOLAMINES, RAPID EYE MOVEMENT SLEEP AND AGGRESSIVE BEHAVIOUR
Version of Record online: 19 JUL 2012
1977 British Pharmacological Society
British Journal of Pharmacology
Volume 61, Issue 3, pages 371–379, November 1977
How to Cite
CARLINI, E.A., LINDSEY, C.J. and TUFIK, S. (1977), CANNABIS, CATECHOLAMINES, RAPID EYE MOVEMENT SLEEP AND AGGRESSIVE BEHAVIOUR. British Journal of Pharmacology, 61: 371–379. doi: 10.1111/j.1476-5381.1977.tb08429.x
- Issue online: 19 JUL 2012
- Version of Record online: 19 JUL 2012
- Received February 28, 1977. Revised April 22, 1977
- 1Previous work from our laboratory has shown that cannabis induces aggressive behaviour in rats that have been deprived of rapid eye movement (REM) sleep. It was suggested that this effect was related to brain catecholamines, with dopamine playing an agonist role and noradrenaline an inhibitory one. The present paper describes new experiments dealing with this subject.
- 2Previous REM sleep-deprivation enhanced both Δ9-tetrahydrocannabinol (THC)-induced hypothermia and nomifensine effects on aggressive behaviour.
- 3A marihuana extract decreased brain dopamine turnover in REM sleep-deprived rats, an effect not observed in non-deprived rats. Noradrenaline metabolism was not altered.
- 4Fighting behaviour was elicited in REM sleep-deprived rats treated with 4 different dopamine-β-hydroxylase inhibitors.
- 5Apomorphine, nomifensine and Δ9-THC administered to non-deprived rats pretreated with bis(4-methyl-1-homopiperanzinyl-thiocarbonyl) disulphide (Fla-63), induced fighting behaviour.
- 6Nomifensine and apomorphine induced fighting in non-deprived rats pretreated with Δ9-THC.
- 7Clonidine inhibited the fighting elicited in REM sleep-deprived rats by either Δ9-THC or Fla-63 pretreatment.
- 8The data are discussed in terms of the influence of REM sleep-deprivation (or the stress associated with deprivation) on the response to dopaminergic drugs and cannabis. Taken together they emphasize the participation of brain dopamine and noradrenaline systems in the aggressive behaviour studied.