Department of Visual Science, Institute of Ophthalmology, Judd Street, London WC1.
Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801
Article first published online: 19 JUL 2012
1988 British Pharmacological Society
British Journal of Pharmacology
Volume 94, Issue 2, pages 443–448, June 1988
How to Cite
Salt, T.E., Wilson, D.G. and Prasad, S.K. (1988), Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801. British Journal of Pharmacology, 94: 443–448. doi: 10.1111/j.1476-5381.1988.tb11546.x
- Issue published online: 19 JUL 2012
- Article first published online: 19 JUL 2012
- Received September 29, 1987, Revised December 10, 1987, Accepted January 13, 1988
- 1Extracellular single neurone recordings were made in the ventrobasal thalamus of urethaneanaesthetized rats.
- 2Iontophoretically and intravenously administered ketamine and MK-801 were found to be selective antagonists of responses of neurones to iontophoretically applied N-methylaspartate.
- 3Both antagonists, administered in N-methylaspartate-selective quantities, reduced the synaptic responses of ventrobasal thalamus neurones to a two-second air jet directed at the peripheral receptive field.