• ACEVES, J., MARISCAL, S., MORRISON, K.E. & YOUNG, J.M. (1985). The binding of doxepin to histamine H1-receptors in guinea-pig and rat brain. Br. J. Pharmacol., 84, 417424.
  • AMBAR, I., KLOOG, Y., SCHVARTZ, I., HAZUM, E. & SOKOLOVSKY, M. (1989). Competitive interaction between endothelin and sarafotoxin: binding and phosphoinositides hydrolysis in rat atria and brain. Biochem. Biophys. Res. Commun., 158, 195201.
  • BYFIELD, R.A., SWAYNE, G.T.G. & WARNER, T.D. (1986). A method for the study of endothelial derived relaxing factors (EDRF) in the isolated perfused rat mesentery. Br. J. Pharmacol., 88, 438P.
  • COLLIER, J. & VALLANCE, P. (1989). Second messenger role for NO widens to nervous and immune systems. Trends Pharmacol. Sci., 10, 427431.
  • GU, X.-H., CASLEY, D. & NAYLER, W. (1989). Specific high-affinity binding sites for 125I-labelled porcine endothelin in rat cardiac membranes. Eur. J. Pharmacol., 167, 281290.
  • FORSTERMANN, U. & NEUFANG, B. (1984). The endothelium-dependent relaxation of rabbit aorta: effects of antioxidants and hydroxylated eicosatetraenoic acids. Br. J. Pharmacol., 82, 765767.
  • HILEY, C.R., PHOON, C.K.L. & THOMAS, G.R. (1987). Acetylcholine relaxation in superior mesenteric arterial bed of the rat is endothelium-dependent and sensitive to antioxidants. Br. J. Pharmacol., 91, 378P.
  • INOUE, A., YANAGISAWA, M., KIMURA, S., KASUYA, Y., MIYAUCHI, T., GOTO, K. & MASAKI, T. (1989). The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A., 86, 28632867.
  • ITOH, Y., YANAGISAWA, M., OHKUBO, S., KIMURA, C., KOSAKA, T., INOUE, A., ISHIDA, N., MITSUI, Y., ONDA, H., FUJINO, M. & MASAKI, T. (1988). Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. FEBS Lett., 231, 440444.
  • KASHIWABARA, T., INAGAKI, Y., OHTA, H., IWAMATSU, A., NOMIZU, M., MORITA, A. & NISHIKORI, K. (1989). Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo. FEBS Lett., 247, 7376.
  • KLOOG, Y., AMBAR, I., SOKOLOVSKY, M., KOCHVA, E., WOLLBERG, Z. & BDOLAH, A. (1988). Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain. Science, 242, 268270.
  • KLOOG, Y., BOUSSO-MITTLER, D., BDOLAH, A. & SOKOLOVSKY, M. (1989). Three apparent receptor subtypes for the endothelin sarafotoxin family. FEBS Lett., 253, 199202.
  • McGREGOR, D.D. (1965). The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat. J. Physiol., 177, 2130.
  • MAGGI, C.A., GIULIANI, S., PATACCHINI, R., ROVERO, P., GIACHETTI, A. & MELI, A. (1989a). The activity of peptides of the endothelin family in various mammalian smooth muscle preparations. Eur. J. Pharmacol., 174, 2531.
  • MAGGI, C.A., GIULIANI, S., PATACCHINI, R., SANTICIOLI, P., ROVERO, P., GIACHETTI, A. & MELI, A. (1989b). The C-terminal hexapeptide, endothelin-(16–21), discriminates between different endothelin receptors. Eur. J. Pharmacol., 166, 121122.
  • MARTIN, W., VILLANI, G.M., JOTHIANANDAN, D. & FURCHGOTT, R.F. (1985). Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J. Pharmacol. Exp. Ther., 232, 708716.
  • MOORE, P.K., AL-SWAYEH, O.A., CHONG, N.W.S., EVANS, R.A. & GIBSON, A. (1990). l-NG-nitro arginine (l-NOARG), a novel, l-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro Br. J. Pharmacol., 99, 408412.
  • POHL, U. & BUSSE, R. (1989). Differential vascular sensitivity to luminally and adventitially applied endothelin-1. J. Cardiovasc. Pharmacol., 13, (Suppl. 5), S188S190.
  • RANDALL, M.D., DOUGLAS, S.A. & HILEY, C.R. (1989). Vascular activities of endothelin-1 and some alanyl substituted analogues in resistance beds of the rat. Br. J. Pharmacol., 98, 685699.
  • SAIDA, K., MITSUI, Y. & ISHIDA, N. (1989). A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. J. Biol. Chem., 264, 1461314616.
  • WARNER, T.D., DE NUCCI, G. & VANE, J.R. (1989). Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat. Eur. J. Pharmacol., 159, 325326.
  • WATANABE, H., MIYAZAKI, H., KONDOH, M., MASUDA, Y., KIMURA, S., YANAGISAWA, M., MASAKI, T. & MURAKAMI, K. (1989). Two distinct types of endothelin receptors are present on chick cardiac membranes. Biochem. Biophys. Res. Commun., 161, 12521259.
  • YANAGISAWA, M., INOUE, A., ISHIKAWA, T., KASUYA, Y., KIMURA, S., KUMAGAYE, S.-I., NAKAJIMA, K., WATANABE, T.X., SAKAKIBARA, S., GOTO, K. & MASAKI, T. (1988a). Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc. Natl. Acad. Sci. U.S.A., 85, 69646967.
  • YANAGISAWA, M., KURIHARA, H., KIMURA, S., TOMOBE, Y., KOBAYASHI, M., MITSUI, Y., YAZAKI, Y., GOTO, K. & MASAKI, T. (1988b). A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 332, 411415.