• BEATTIE, D. T., BERESFORD, I. J., CONNOR, H. E., MARSHALL, F. M., HAWCOCK, A. B., HAGAN, R., BOWERS, J., BIRCH, P. J. & WARD, P. (1995). The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist. Br. J. Pharmacol., 116, 31493157.
  • BOUNTRA, C., BUNCE, K., DALE, T., GARDNER, C., JORDAN, C., TWISSELL, D. & WARD, P. (1993). Anti-emetic profile of a nonpeptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. Eur. J. Pharmacol., 249, R3R4.
  • CUBEDDU, L. X., HOFFMAN, I.S., FUENMAYOR, N. T. & MALAVE, J. J. (1992). Changes in serotonin metabolism in cancer patients: its relationship to nausea and vomiting induced by chemotherapeutic drugs. Br. J. Cancer, 66, 198203.
  • GARDNER, C. J., BOUNTRA, C., BUNCE, K. T., DALE, T. J., JORDAN, C.C., TWISSELL, D. J. & WARD, P. (1994). Anti-emetic activity of neurokinin NK1 receptor antagonists is mediated centrally in the ferret. Br. J. Pharmacol., 112, 516P.
  • HARGREAVES, R. J., TATTERSHALL, F. D., RYCROFT, W., WOODFORD, K., LADDUWAHETTY, T., KEOWN, L., MERCHANT, K., SWAIN, S., MACLEOD, A., BAKER, R., FRANCIS, B., BURNS, D., BER, E., CASCIERI, P., METZGER, J., MACINTYRE, D. E., WILLIAMSON, A.R., IVERSEN, L. L. & HILL, R. G. (1994). Evidence that the anti-emetic effects of NK1 receptor antagonists are centrally mediated. Can. J. Physiol. Pharmacol., 72, (suppl. 2), P45.
  • KAMATO, T., MIYATA, K., ITO, H., YUKI, H., YAMANO, M. & HONDA, K. (1991). Antiemetic effect of YM060, a potent and selective (5-HT)3 receptor antagonist in ferrets and dogs. Jap. J. Pharmacol., 57, 387395.
  • LUCOT, J. B. (1989). Blockade of 5-hydroxytryptamine3 receptors prevents cisplatin-induced but not motion- or xylazine-induced emesis in the cat. Pharmacol. Biochem. Behav., 32, 207210.
  • MCRITCHIE, D. A. & TÖRK, I. (1994). Distribution of substance P-like immunoreactive neurons and terminals throughout the nucleus of the solitary tract in the human brainstem. J. Comp. Neurol., 343, 83101.
  • MALEY, B. & ELDE, R. (1982). Immunohistochemical localization of putative neurotransmitters within the feline nucleus tractus solitarius. Neuroscience, 7, 24692490.
  • MALEY, B., MULLETT, T. & ELDE, R. (1983). The nucleus tractus solitarius of the cat: A comparison of golgi impregnated neurons with methionine enkephalin and substance P-immunoreactive neurons. J. Comp. Neurol., 217, 405417.
  • MAUBACH, K. A., JONES, R.S.G., STRATTON, S. C. & GALE, J. D. (1995). Autoradiographic distribution of substance P binding sites in the brainstem of rat and ferret. Br. J. Pharmacol., 116, 249p.
  • PITKANEN, M. T., NIEMI, L., TUOMINEN, M. K. & ROSENBERG, P. H. (1993). Effect of tropisetron, a 5-HT3 receptor antagonist, on analgesia and nausea after intrathecal morphine. Br. J. Anaesth., 71, 681684.
  • RICHE, D., POMMERY, J. & MENETREY, D. (1990). Neuropeptides and catecholamines in efferent projections of the nuclei of the solitary tract in the rat. J. Comp. Neurol., 293, 399424.
  • RUDD, J. A., COSTALL, B., NAYLOR, R. J. & TATTERSHALL, F. D. (1990). The emetic action of copper sulfate in the ferret. Eur. J. Pharmacol., 183, 1213.
  • SJOLUND, K., SANDEN, G., HÅKANSON, R. & SUNDLER, F. (1983). Endocrine cells in human intestine: An immunocytochemical study. Gastroenterol., 85, 11201130.
  • STOTT, J. R., BARNES, G.R., WRIGHT, R. J. & RUDDOCK, C. J. (1989). The effect on motion sickness and oculomotor function of GR 38032F, a 5-HT3 receptor antagonist with anti-emetic properties. Br. J. Clin. Pharmacol., 27, 147157.
  • SUNDLER, F., ALUMETS, J. & HÅKANSON, R. (1977). 5-Hydroxytryptamine-containing enterochromaffin cells: storage site of substance P. Acta Physiol. Scand., (Suppl. 452), 121123.
  • TATTERSHALL, F. D., RYCROFT, W., HARGREAVES, R. J. & HILL, R. G. (1993). The tachykinin NK1 receptor antagonist CP-99,994 attenuates cisplatin-induced emesis in the ferret. Eur. J. Pharmacol., 250, R5R6.
  • TATTERSHALL, F. D., RYCROFT, W., HILL, R. G. & HARGREAVES, R. J. (1994). Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neurokinin1 receptor antagonist CP-99,994. Neuropharmacol., 33, 259260.
  • THOMPSON, P. I., BINGHAM, S., ANDREWS, P.L.R., PATEL, N., JOEL, S. P. & SLEVIN, M. L. (1992). Morphine 6-glucuronide: a metabolite of morphine with greater emetic potency than morphine in the ferret. Br. J. Pharmacol., 106, 38.
  • UENOI, S., MATSUKI, N. & SAITO, H. (1988). Suncus murinus as a new experimental model for motion sickness. Life Sci., 43, 413420.
  • WATSON, J. W., GONSALVES, S. F., FOSSA, A. A., MCLEAN, S., SEEGER, T., OBACH, S. & ANDREWS, P.L.R. (1995). The antiemetic effects of CP-99,994 in the ferret and the dog - role of the NK1 receptor. Br. J. Pharmacol., 115, 8494.
  • YAMAZOE, M., SHIOSAKA, S., SHIBASAKA, T., LING, N., TATEISHI, K., HASHIMURA, E., HAMAOKA, T., RIMMEL, J., MATSUO, H. & TOHYAMA, M. (1984). Distribution of six neuropeptides in the nucleus tractus solitarii of the rat: An immunohistochemical analysis. Neuroscience, 13, 12431266.