Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA


Elias Fattal, UMR CNRS 8612, Univ. Paris Sud 11, Faculté de Pharmacie, 5 Rue Jean Baptiste Clément, 92296 Châtenay-Malabry, France. E-mail:


Antisense oligonucleotides and small interfering RNA have enormous potential for the treatment of a number of diseases, including cancer. However, several impediments to their widespread use as drugs still have to be overcome: in particular their lack of stability in physiological fluids and their poor penetration into cells. Association with or encapsulation within nano- and microsized drug delivery systems could help to solve these problems. In this review, we describe the progress that has been made using delivery systems composed of natural or synthetic polymers in the form of complexes, nanoparticles or microparticles.

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